Journal Article

Valganciclovir for Symptomatic Congenital Cytomegalovirus Disease

Vanchiere, John A, Kuo, Huichien, Sabo, Diane L, Acosta, Edward P, Finn, Adam, Shane, Andi L, Englund, Janet A, Estrada, Benjamin, DeBiasi, Roberta L, Gutierrez, Kathleen, Giles, Dusty, Dennehy, Penelope H, Jester, Penelope M, Caserta, Mary T, Weiner, Leonard B, Ashouri, Negar, Bocchini, Joseph A, Kimberlin, David W, Whitworth, M. Suzanne, Halasa, Natasha, Simonsen, Kari, Sood, Sunil K, Aban, Inmaculada, Michaels, Marian G, Han, Jin-Young, Arav-Boger, Ravit, Jacobs, Richard F, Homans, James, Sharland, Michael, James, Scott H, Luck, Suzanne, Ahmed, Amina, Whitley, Richard J, Sánchez, Pablo J, Prichard, Mark N, Fowler, Sandra, Lujan-Zilbermann, Jorge, Palmer, April, Griffiths, Paul D, Storch, Gregory A, Romero, José R, Griffin, Jill, Woods, Charles R, Abzug, Mark J

2015

Overview

Cytomegalovirus is an important cause of disease in the newborn. The authors report data from a randomized trial of an extension of valganciclovir therapy from 6 weeks to 6 months for symptomatic CMV disease in newborns. Congenital cytomegalovirus (CMV) infection is the leading nongenetic cause of sensorineural hearing loss 1 – 4 and is the most frequent known viral cause of mental retardation 5 ; the infection affects 0.6 to 0.7% of live births in industrialized countries. 6 – 8 A total of 10% of congenitally infected neonates have symptomatic disease at birth, of whom 35% have sensorineural hearing loss, up to two thirds have neurologic deficits, and 4% die during the newborn period. 7 – 11 Although congenital CMV infection is rare overall, it accounts for 21% of children with hearing loss at birth and 24% of those with hearing loss at . . .

• Publisher: Massachusetts Medical Society
• Subject: Allergies / Antiviral Agents - administration & dosage / Antiviral Agents - adverse effects / Antiviral drugs / Audiometry / Central nervous system / Child Development / Congenital diseases / Cytomegalovirus / Cytomegalovirus Infections - complications / Cytomegalovirus Infections - congenital / Cytomegalovirus Infections - drug therapy / Double-Blind Method / Drug Administration Schedule / Drug therapy / Ear / Ears & hearing / Evoked Potentials, Auditory, Brain Stem / Ganciclovir / Ganciclovir - administration & dosage / Ganciclovir - adverse effects / Ganciclovir - analogs & derivatives / Gestational Age / Hearing loss / Hearing Loss, Sensorineural - prevention & control / Hearing Loss, Sensorineural - virology / Humans / Infant, Newborn / Infectious diseases / Intravenous administration / Neonates / Neutropenia / Neutropenia - chemically induced / Valganciclovir