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Complete biosynthetic pathway of furochromones in Saposhnikovia divaricata and its evolutionary mechanism in Apiaceae plants
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Complete biosynthetic pathway of furochromones in Saposhnikovia divaricata and its evolutionary mechanism in Apiaceae plants
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Journal Article
Complete biosynthetic pathway of furochromones in Saposhnikovia divaricata and its evolutionary mechanism in Apiaceae plants
2025
Overview
Furochromones are specific bioactive secondary metabolites of many Apiaceae plants. Their biosynthesis remains largely unexplored. In this work, we dissect the complete biosynthetic pathway of major furochromones in the medicinal plant
Saposhnikovia divaricata
by characterizing prenyltransferase, peucenin cyclase, methyltransferase, hydroxylase, and glycosyltransferases. De novo biosynthesis of prim-
O
-glucosylcimifugin and 5-
O
-methylvisamminoside is realized in
Nicotiana benthamiana
leaves. Through comparative genomic and transcriptomic analyses, we further find that proximal duplication and high expression of a pentaketide chromone synthase gene
SdPCS
, together with the presence of a lineage-specific peucenin cyclase gene
SdPC
, lead to the predominant accumulation of furochromones in the roots of
S. divaricata
among surveyed Apiaceae plants. This study paves the way for metabolic engineering production of furochromones, and sheds light into evolutionary mechanisms of furochromone biosynthesis among Apiaceae plants.
The complete biosynthetic pathway of Prim-
O
-Glucosylcimifugin and 5-
O
-Methylvisamminoside in
Saposhnikovia divaricata
is resolved and their de novo biosynthesis is reconstructed in
Nicotiana benthamiana
leaves. The evolutionary mechanisms of furochromone biosynthesis among Apiaceae plants is further analyzed.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
