Asset Details
Do you wish to reserve the book?
Highly sensitive cancer detection using an open D-channel PCF-based SPR biosensor
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Highly sensitive cancer detection using an open D-channel PCF-based SPR biosensor
Do you wish to request the book?
Highly sensitive cancer detection using an open D-channel PCF-based SPR biosensor
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Highly sensitive cancer detection using an open D-channel PCF-based SPR biosensor
2025
Overview
Surface plasmon resonance (SPR) is a technique utilized for the label-free detection of cancer cells. In this analysis, we introduce a photonic crystal fiber (PCF) designed with an open D-channel, featuring a layer of gold (Au) and titanium dioxide (TiO
2
) as the plasmonic material. This effectively reduces the gap between the fiber core and the gold layer, resulting in improved performance. Additionally, incorporating TiO
2
between the gold and the silica substrate enhances their adhesion and contributes to a more robust structure. We conducted a comprehensive numerical analysis of the suggested biosensor utilizing the finite element method (FEM) integrated with perfectly matched layers (PML) within the COMSOL Multiphysics simulation tool. The design of this sensor is specifically intended for the detection of molecules with a refractive index (RI) varying from 1.25 to 1.43, achieving an impressive peak spectral sensitivity of 47,000 nm/RIU. For this purpose, we investigated RI values from 1.36 to 1.401 concerning six different cancer cell types. The highest spectral sensitivity is 5214.285 nm/RIU, while the amplitude sensitivity is -1481.1 RIU
− 1
, which has been recorded for MCF-7 and HeLa cells. This proposed sensor shows improved amplitude sensitivity, signal-to-noise ratio (SNR), full width at half maximum (FWHM), figure of merit (FOM), and detection limit (DL) compared to existing biosensors, highlighting its potential for biosensing applications. Additionally, it is significant that according to the results, HeLa cells have a maximum resolution of 1.19 × 10
− 5
RIU and a FOM of 350 RIU
− 1
.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 639/624
/ Biosensing Techniques - instrumentation
/ Biosensing Techniques - methods
/ Cancer
/ Gold
/ Humanities and Social Sciences
/ Humans
/ Photonic crystal fiber (PCF)
/ Science
/ Silica
/ Surface plasmon resonance (SPR)
/ Surface Plasmon Resonance - instrumentation
