Asset Details
Do you wish to reserve the book?
Effect of Hormone Therapy on Lipoprotein Subfractions in Early and Late Postmenopausal Women
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Effect of Hormone Therapy on Lipoprotein Subfractions in Early and Late Postmenopausal Women
Do you wish to request the book?
Effect of Hormone Therapy on Lipoprotein Subfractions in Early and Late Postmenopausal Women
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Effect of Hormone Therapy on Lipoprotein Subfractions in Early and Late Postmenopausal Women
2025
Overview
Abstract
Context
The Early vs Late Intervention Trial with Estradiol (ELITE) showed that hormone therapy (HT) reduced atherosclerosis progression among early but not late postmenopausal women (PMW).
Objective
Determined by time-since-menopause (1) HT effects on lipids and lipoprotein particle subfractions (LPs), (2) associations of estradiol (E2) level with lipids and LPs, (3) associations of lipids and LPs with atherosclerosis progression.
Design
Randomized controlled trial stratified by time-since-menopause.
Setting
Academic institution.
Participants
Healthy postmenopausal women.
Intervention
Oral E2 with/without sequential vaginal progesterone.
Main Outcome Measures
Standard lipids and 21 LPs quantitated by ion mobility every 6 months.
Results
Among 562 PMW (240 early, 322 late), HT significantly increased total triglycerides (TG), high-density lipoprotein (HDL) cholesterol, small low-density lipoproteins (LDL), large HDL, and TG/C ratio in LDL and HDL and decreased LDL-cholesterol, total very low density lipoproteins (VLDL), small VLDL, intermediate-density lipoproteins, large LDL, and LDL peak diameter. HT showed no lipid or LP differences between time-since-menopause. Associations of E2 level with lipids and LPs explained the HT effects. Despite the nonsignificant P interaction by time-since-menopause, we observed that very small LDL and total HDL LPs were associated with atherosclerosis progression in late PMW.
Conclusion
HT effects on standard lipids and LPs are consistent with the literature. HT has similar effect on lipids and LPs in early and late PMW. Novel findings include discordant effects of HT on TG and VLDL particles, which can be explained by increased catabolism of atherogenic remnants of TG-rich lipoproteins. Our findings extend the well-known HT effects on standard lipids and LPs that may contribute to the beneficial effects on atherosclerosis progression in PMW.
Publisher
Oxford University Press
Subject
/ Aged
/ Atherosclerosis - prevention & control
/ Clinical
/ Estradiol - administration & dosage
/ Estrogen Replacement Therapy
/ Female
/ Humans
/ Lipids
/ Lipoproteins (very low density)
/ Lipoproteins - classification
/ Postmenopause - drug effects
/ Progesterone - administration & dosage
/ Women
