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Inhaled Molgramostim Therapy in Autoimmune Pulmonary Alveolar Proteinosis

by Papiris, Spyros A , Bonella, Francesco , Yamaguchi, Etsuro , Waterer, Grant , Bendstrup, Elisabeth , Inoue, Yoshikazu , Jouneau, Stéphane , Trapnell, Bruce C , Kreuter, Michael , Baba, Tomohisa , Jouhikainen, Taneli , Cetinkaya, Erdogan , Kramer, Mordechai R , Tarnow, Inge , Campo, Ilaria , Morgan, Cliff , Veltkamp, Marcel , Ilkovich, Mikhail M , Ganslandt, Cecilia

in Administration, Inhalation / Adult / Alveoli / Autoimmune Diseases - drug therapy / Autoimmune Diseases - physiopathology / Autoimmune Diseases - therapy / Biomarkers / Blood pressure / Bronchoalveolar Lavage / Colony-stimulating factor / Disease / Double-Blind Method / Drug Administration Schedule / Exercise Tolerance / FDA approval / Female / Granulocyte-macrophage colony-stimulating factor / Granulocyte-Macrophage Colony-Stimulating Factor - administration & dosage / Granulocyte-Macrophage Colony-Stimulating Factor - adverse effects / Health Status / Humans / Hypoxemia / Inhalation / Lavage / Life Sciences / Male / Middle Aged / Oxygen - blood / Pathogenesis / Pulmonary Alveolar Proteinosis - drug therapy / Pulmonary Alveolar Proteinosis - physiopathology / Pulmonary Alveolar Proteinosis - therapy / Pulmonary Gas Exchange / Rare diseases / Recombinant Proteins - administration & dosage / Recombinant Proteins - adverse effects / Sediments / Statistical analysis / Surfactants / Walk Test

2020

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Inhaled Molgramostim Therapy in Autoimmune Pulmonary Alveolar Proteinosis

2020

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2020

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Journal Article

Inhaled Molgramostim Therapy in Autoimmune Pulmonary Alveolar Proteinosis

Papiris, Spyros A,

Bonella, Francesco,

Yamaguchi, Etsuro,

Waterer, Grant,

Bendstrup, Elisabeth,

Inoue, Yoshikazu,

Jouneau, Stéphane,

Trapnell, Bruce C,

Kreuter, Michael,

Baba, Tomohisa,

Jouhikainen, Taneli,

Cetinkaya, Erdogan,

Kramer, Mordechai R,

Tarnow, Inge,

Campo, Ilaria,

Morgan, Cliff,

Veltkamp, Marcel,

Ilkovich, Mikhail M,

Ganslandt, Cecilia

2020

Overview

Patients with autoimmune pulmonary alveolar proteinosis received inhaled molgramostim or matching placebo for 24 weeks. Patients receiving molgramostim had greater improvement in pulmonary gas transfer and alleviation of symptoms than those receiving placebo.

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Publisher

Massachusetts Medical Society

Subject

Administration, Inhalation

/ Adult

/ Alveoli

/ Autoimmune Diseases - drug therapy

/ Autoimmune Diseases - physiopathology

/ Autoimmune Diseases - therapy

/ Biomarkers