Asset Details
Do you wish to reserve the book?
Interaction between organochlorines and the AHR gene, and risk of non-Hodgkin lymphoma
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Interaction between organochlorines and the AHR gene, and risk of non-Hodgkin lymphoma
Do you wish to request the book?
Interaction between organochlorines and the AHR gene, and risk of non-Hodgkin lymphoma
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Interaction between organochlorines and the AHR gene, and risk of non-Hodgkin lymphoma
2010
Overview
Background Plasma organochlorines have been implicated to increase the risk of non-Hodgkin lymphoma (NHL), and interaction with the aryl hydrocarbon receptor gene (AHR) may modify this risk. Methods In this case-control study conducted in British Columbia, Canada, five single nucleotide polymorphisms (SNPs) of AHR were genotyped in 422 NHL cases and 459 controls to measure the association between individual SNPs, haplotypes, and risk of NHL. Pre-chemotherapy organochlorine levels were measured and gene-environment interaction analysis was performed. Results The IVS1 + 4640G/A SNP was significantly associated with NHL risk, with an odds ratio of 1.32 (95% CI = 1.05-1.65) for G/A or A/A genotypes compared to the G/G genotype. Interactions were observed with PCB 118, a known inducer of AHR, and chlordane-related analytes oxychlordane and trans-nonachlor, although no interactions were statistically significant after controlling for multiple comparisons. The observed interactions were consistent across NHL subtypes. Conclusion Results suggest that the AHR gene may play a role in determining the risk of NHL with exposure to organochlorines, and highlight the importance of understanding gene-environment interactions.
Publisher
Dordrecht : Springer Netherlands,Springer,Springer Netherlands,Springer Nature B.V
Subject
/ Aged
/ Alleles
/ Basic Helix-Loop-Helix Transcription Factors
/ Biomedical and Life Sciences
/ Cancer
/ Dioxins
/ Environmental Pollutants - blood
/ Exons
/ Genes
/ Genetic Predisposition to Disease
/ Genotype
/ Humans
/ Hydrocarbons, Chlorinated - blood
/ Kinases
/ Lymphoma
/ Lymphoma, Non-Hodgkin - epidemiology
/ Lymphoma, Non-Hodgkin - genetics
/ Oncology
/ PCB
/ Plasma
/ Polymorphism, Single Nucleotide
/ Receptors, Aryl Hydrocarbon - genetics
/ Toxicity
