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Multisystemic Inflammatory Syndrome Temporally Associated with COVID-19 in a Regional Pediatric Hospital from México

by Madrid-Gómez-Tagle, José Antonio , Espinosa-Padilla, Sara Elva , Suárez-Soto, Jorge Iván , Delgado-Amézquita, Carolina , Robledo-Martínez, Angelina Ingrid , Hernández-Cadena, Sarai Eunice , Otamendi-Canales, Octavio , Jiménez-Osorio, Angélica Saraí , Hurtado del Ángel, Rubén Genaro , Godínez-Hernández, Brenda , Barroso-Santos, Joel , Sánchez-Reyes, Beatriz Adriana , Arteaga-García, Felipe , Langarica-Bulos, Mónica

in Age / Biomarkers / Body mass index / children / Communication / COVID-19 / Creatinine / Ferritin / Fever / Gamma globulin / Globulins / Hospitals / Immunoglobulin G / Inflammation / Leukemia / Long-term effects / Lymphopenia / Males / multisystemic inflammatory syndrome / Neutropenia / Normal distribution / Patients / Pediatrics / Pericarditis / Severe acute respiratory syndrome coronavirus 2 / Thrombocytopenia / Ultrasonic imaging

2023

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Multisystemic Inflammatory Syndrome Temporally Associated with COVID-19 in a Regional Pediatric Hospital from México

2023

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Multisystemic Inflammatory Syndrome Temporally Associated with COVID-19 in a Regional Pediatric Hospital from México

2023

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Journal Article

Multisystemic Inflammatory Syndrome Temporally Associated with COVID-19 in a Regional Pediatric Hospital from México

Madrid-Gómez-Tagle, José Antonio,

Espinosa-Padilla, Sara Elva,

Suárez-Soto, Jorge Iván,

Delgado-Amézquita, Carolina,

Robledo-Martínez, Angelina Ingrid,

Hernández-Cadena, Sarai Eunice,

Otamendi-Canales, Octavio,

Jiménez-Osorio, Angélica Saraí,

Hurtado del Ángel, Rubén Genaro,

Godínez-Hernández, Brenda,

Barroso-Santos, Joel,

Sánchez-Reyes, Beatriz Adriana,

Arteaga-García, Felipe,

Langarica-Bulos, Mónica

2023

Overview

Multisystemic inflammatory syndrome (MIS-C) is an inflammatory condition temporally associated with COVID-19 in children; nevertheless, the clinical and immunologic spectrum of MIS-C is heterogeneous, and its long-term effects are unknown. During the period of August 2020 to December 2021, a total of 52 MIS-C cases were confirmed in pediatric patients from the Hospital del Niño DIF Hidalgo, diagnosed using criteria from the World Health Organization. All patients had serologic IgG confirmation of SARS-CoV2, the mean age of the patients was 7 years, and 94% of the patients did not have a previous underlying disease. In addition to the presentation of lymphopenia, neutropenia, and thrombocytopenia, elevations in D-dimer and ferritin levels were observed in all patients. There was clinical improvement with intravenous gamma globulin and corticosteroid treatment.

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