Asset Details
Do you wish to reserve the book?
Anti-Allergic and Anti-Inflammatory Effects of Undecane on Mast Cells and Keratinocytes
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Anti-Allergic and Anti-Inflammatory Effects of Undecane on Mast Cells and Keratinocytes
Do you wish to request the book?
Anti-Allergic and Anti-Inflammatory Effects of Undecane on Mast Cells and Keratinocytes
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Anti-Allergic and Anti-Inflammatory Effects of Undecane on Mast Cells and Keratinocytes
2020
Overview
The critical roles of keratinocytes and resident mast cells in skin allergy and inflammation have been highlighted in many studies. Cyclic adenosine monophosphate (cAMP), the intracellular second messenger, has also recently emerged as a target molecule in the immune reaction underlying inflammatory skin conditions. Here, we investigated whether undecane, a naturally occurring plant compound, has anti-allergic and anti-inflammatory activities on sensitized rat basophilic leukemia (RBL-2H3) mast cells and HaCaT keratinocytes and we further explored the potential involvement of the cAMP as a molecular target for undecane. We confirmed that undecane increased intracellular cAMP levels in mast cells and keratinocytes. In sensitized mast cells, undecane inhibited degranulation and the secretion of histamine and tumor necrosis factor α (TNF-α). In addition, in sensitized keratinocytes, undecane reversed the increased levels of p38 phosphorylation, nuclear factor kappaB (NF-κB) transcriptional activity and target cytokine/chemokine genes, including thymus and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC) and interleukin-8 (IL-8). These results suggest that undecane may be useful for the prevention or treatment of skin inflammatory disorders, such as atopic dermatitis, and other allergic diseases.
Publisher
MDPI AG,MDPI
Subject
/ Allergy
/ Anti-Allergic Agents - pharmacology
/ Anti-Inflammatory Agents - pharmacology
/ Antigens
/ cAMP
/ Cell Degranulation - drug effects
/ Cell Survival - drug effects
/ Cells
/ Ethylenediaminetetraacetic acid
/ Humans
/ Inflammation Mediators - metabolism
/ Keratinocytes - drug effects
/ Kinases
/ Leukemia
/ Ligands
/ Proteins
/ Skin
/ undecane
