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Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection
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Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection
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Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection
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Journal Article
Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection
2016
Overview
Zika virus (ZIKV), a mosquito-borne flavivirus with homology to Dengue virus (DENV), has become a public health emergency. By characterizing memory lymphocytes from ZIKV-infected patients, we dissected ZIKV-specific and DENV-cross-reactive immune responses. Antibodies to nonstructural protein 1 (NS1) were largely ZIKV-specific and were used to develop a serological diagnostic tool. In contrast, antibodies against E protein domain l/ll (EDI/II) were cross-reactive and, although poorly neutralizing, potently enhanced ZIKV and DENV infection in vitro and lethally enhanced DENV disease in mice. Memory T cells against NS1 or E proteins were poorly cross-reactive, even in donors preexposed to DENV. The most potent neutralizing antibodies were ZIKV-specific and targeted EDIII or quaternary epitopes on infectious virus. An EDIII-specific antibody protected mice from lethal ZIKV infection, illustrating the potential for antibody-based therapy.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Antibodies, Monoclonal - chemistry
/ Antibodies, Monoclonal - immunology
/ Antibodies, Monoclonal - therapeutic use
/ Antibodies, Neutralizing - chemistry
/ Antibodies, Neutralizing - immunology
/ Antibodies, Neutralizing - therapeutic use
/ Antibodies, Viral - chemistry
/ Antibodies, Viral - immunology
/ Antibodies, Viral - therapeutic use
/ Humans
/ Immunodominant Epitopes - immunology
/ Mice
/ Proteins
/ Viral Envelope Proteins - immunology
/ Viral Nonstructural Proteins - immunology
/ Viruses
/ Zika Virus Infection - immunology
