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Diabetes Mellitus and Heart Failure
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Journal Article
Diabetes Mellitus and Heart Failure
2017
Overview
Epidemiologic and clinical data from the last 2 decades have shown that the prevalence of heart failure in diabetes is very high, and the prognosis for patients with heart failure is worse in those with diabetes than in those without diabetes. Experimental data suggest that various mechanisms contribute to the impairment in systolic and diastolic function in patients with diabetes, and there is an increased recognition that these patients develop heart failure independent of the presence of coronary artery disease or its associated risk factors. In addition, current clinical data demonstrated that treatment with the sodium glucose cotransporter 2 inhibitor empagliflozin reduced hospitalization for heart failure in patients with type 2 diabetes mellitus and high cardiovascular risk. This review article summarizes recent data on the prevalence, prognosis, pathophysiology, and therapeutic strategies to treat patients with diabetes and heart failure.
Publisher
Elsevier Inc,Elsevier Limited
Subject
/ Benzhydryl Compounds - therapeutic use
/ Diabetes
/ Diabetes Mellitus, Type 2 - drug therapy
/ Diabetes Mellitus, Type 2 - epidemiology
/ Diabetes Mellitus, Type 2 - pathology
/ Diabetes Mellitus, Type 2 - physiopathology
/ Diabetic Angiopathies - drug therapy
/ Diabetic Angiopathies - epidemiology
/ Diabetic Angiopathies - pathology
/ Diabetic Angiopathies - physiopathology
/ Glucosides - therapeutic use
/ Heart
/ Heart Failure - drug therapy
/ Heart Failure - epidemiology
/ Heart Failure - physiopathology
/ Humans
/ Hypoglycemic Agents - therapeutic use
/ Patients
/ Sodium
