Journal Article

Phase Ib Study of Ulixertinib Plus Gemcitabine and Nab-Paclitaxel in Patients with Metastatic Pancreatic Adenocarcinoma

Trikalinos, Nikolaos A, Der, Channing J, Suresh, Rama, Knoerzer, Deborah, Pedersen, Katrina S, Amin, Manik A, Park, Haeseong, Kreider, Brent, Liu, Jingxia, Lim, Kian-Huat, Wang-Gillam, Andrea, Reddy, Anupama, Grierson, Patrick M, Tan, Benjamin

2023

Overview

Abstract Background Ulixertinib is a novel oral ERK inhibitor that has shown promising single-agent activity in a phase I clinical trial that included patients with RAS-mutant cancers. Methods We conducted a phase Ib trial combining ulixertinib with gemcitabine and nab-paclitaxel (GnP) for untreated metastatic pancreatic adenocarcinoma. The trial comprised a dose de-escalation part and a cohort expansion part at the recommended phase II dose (RP2D). Primary endpoint was to determine the RP2D of ulixertinib plus GnP and secondary endpoints were to assess toxicity and safety profile, biochemical and radiographic response, progression-free survival (PFS) and overall survival (OS). Results Eighteen patients were enrolled. Ulixertinib 600 mg PO twice daily (BID) with GnP was initially administered but was de-escalated to 450 mg BID as RP2D early during dose expansion due to poor tolerability, which ultimately led to premature termination of the study. Common treatment-related adverse events (TRAEs) were anemia, thrombocytopenia, rash and diarrhea. For 5 response evaluable patients, one patient achieved a partial response and 2 patients achieved stable disease. For 15 patients who received the triplet, median PFS and OS were 5.46 and 12.23 months, respectively. Conclusion Ulixertinib plus GnP had similar frequency of grade ≥3 TRAEs and potentially efficacy as GnP, however was complicated by a high rate of all-grade TRAEs (ClinicalTrials.gov Identifier: NCT02608229). Ulixertinib has shown promising single-agent activity in a phase I clinical trial that included patients with RAS-mutant cancers. This phase Ib trial combined ulixertinib with gemcitabine and nab-paclitaxel for untreated metastatic pancreatic adenocarcinoma. Results are reported here.

• Publisher: Oxford University Press
• Subject: Adenocarcinoma / Adenocarcinoma - drug therapy / Adenocarcinoma - pathology / Albumins - adverse effects / Analysis / Anemia / Antimitotic agents / Antineoplastic agents / Antineoplastic Combined Chemotherapy Protocols - adverse effects / Cancer / Care and treatment / Clinical Trial Results / Clinical trials / Deoxycytidine / Development and progression / Diagnosis / Diarrhea / Dosage and administration / Gemcitabine / Gene expression / Genetic aspects / Humans / Metastasis / Paclitaxel / Pancreatic cancer / Pancreatic Neoplasms - drug therapy / Pancreatic Neoplasms - pathology / Product development / RNA sequencing / Treatment Outcome