Journal Article

Glucose-lowering effects of orally administered superoxide dismutase in type 2 diabetic model rats

Guo, Jingke, Rao, Pingfan, Jin, Xuepu, Hu, Yujia, Liu, Shutao, Gao, Xiaolu, Zhao, Dan, Liu, Hangqi, Pan, Chaoyi

2022

Overview

Superoxide dismutase (SOD) is an enzyme found in most food sources, might be a candidate to reduce oxidative damage to intestinal barrier, thereby ameliorating the vicious circle between hyperglycemia and the oxidative damage. Here we report the oral administration of SOD, liposome-embedded SOD (L-SOD), and SOD hydrolysate to type 2 diabetic model rats to confirm this hypothesis. Oxidative damage severity in model rat intestine was indicated by malondialdehyde level, GSSG/GSH ratio, and antioxidant enzyme activity. The damage was significantly repaired by L-SOD. Furthermore, blood glucose and related indexes correlated well not only with oxidative damage results but also with indexes indicating physical intestinal damage such as colon density, H&E staining, immunohistochemical analysis of the tight junction proteins occludin and ZO-1 in the colon, as well as lipopolysaccharide and related inflammatory cytokine levels. The order of the magnitude of the effects of these SOD preparations was L-SOD > SOD > SOD hydrolysate. These data indicate that orally administered SOD can exhibit glucose-lowering effect via targeting the intestine of diabetic rats and systemic lipopolysaccharide influx.

• Publisher: Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
• Subject: 631/443 / 692/4020 / Chemistry / Chemistry and Materials Science / Chemistry/Food Science / Colon / Cytokines / Damage / Diabetes / Diabetes mellitus / Enzymatic activity / Enzyme activity / Enzymes / Food Microbiology / Food Science / Food sources / Glucose / Hydrolysates / Hyperglycemia / Inflammation / Intestine / Lipopolysaccharides / Nutrition / Oral administration / Oxidation / Superoxide dismutase / Zonula occludens-1 protein