Asset Details
Do you wish to reserve the book?
Lipopolysaccharide Alters Motivated Behavior in a Monetary Reward Task: a Randomized Trial
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Lipopolysaccharide Alters Motivated Behavior in a Monetary Reward Task: a Randomized Trial
Do you wish to request the book?
Lipopolysaccharide Alters Motivated Behavior in a Monetary Reward Task: a Randomized Trial
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Lipopolysaccharide Alters Motivated Behavior in a Monetary Reward Task: a Randomized Trial
2017
Overview
Inflammation-induced sickness is associated with a large set of behavioral alterations; however, its motivational aspects remain poorly explored in humans. The present study assessed the effect of lipopolysaccharide (LPS) administration at a dose of 2 ng/kg of body weight on motivation in 21 healthy human subjects in a double-blinded, placebo (saline)-controlled, cross-over design. Incentive motivation and reward sensitivity were measured using the Effort Expenditure for Rewards Task (EEfRT), in which motivation for high-effort/high-reward trials vs low-effort/low-reward trials are manipulated by variations in reward magnitude and probability to win. Because of the strong interactions between sleepiness and motivation, the role of sleepiness was also determined. As expected, the probability to win predicted the choice to engage in high-effort/high-reward trials; however, this occurred at a greater extent after LPS than after saline administration. This effect was related to the level of sleepiness. Sleepiness increased motivation to choose the high-effort/high-reward mode of response, but only when the probability to win was the highest. LPS had no effect on reward sensitivity either directly or via sleepiness. These results indicate that systemic inflammation induced by LPS administration causes motivational changes in young healthy subjects, which are associated with sleepiness. Thus, despite its association with energy-saving behaviors, sickness allows increased incentive motivation when the effort is deemed worthwhile.
Publisher
Nature Publishing Group
Subject
/ Behavior
/ Choice Behavior - drug effects
/ Female
/ Humans
/ Illness Behavior - physiology
/ Inflammation - chemically induced
/ Inflammation - physiopathology
/ Lipopolysaccharides - administration & dosage
/ Lipopolysaccharides - pharmacology
/ Male
/ Original
/ Psychomotor Performance - drug effects
/ Reward
