Asset Details
Do you wish to reserve the book?
Constructing bio-layer of heparin and type IV collagen on titanium surface for improving its endothelialization and blood compatibility
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Constructing bio-layer of heparin and type IV collagen on titanium surface for improving its endothelialization and blood compatibility
Do you wish to request the book?
Constructing bio-layer of heparin and type IV collagen on titanium surface for improving its endothelialization and blood compatibility
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Constructing bio-layer of heparin and type IV collagen on titanium surface for improving its endothelialization and blood compatibility
2016
Overview
The modification of cardiovascular stent surface for a better micro-environment has gradually changed to multi-molecule, multi-functional designation. In this study, heparin (Hep) and type IV collagen (IVCol) were used as the functional molecule to construct a bifunctional micro-environment of anticoagulation and promoting endothelialization on titanium (Ti). The surface characterization results (AFM, Alcian Blue 8GX Staining and fluorescence staining of IVCol) indicated that the bio-layer of Hep and IVCol were successfully fabricated on the Ti surface through electrostatic self-assembly. The APTT and platelet adhesion test demonstrated that the bionic layer possessed better blood compatibility compared with Ti surface. The adhesion, proliferation, migration and apoptosis tests of endothelial cells proved that the Hep/IVCol layer was able to enhance the endothelialization of the Ti surface. The in vivo animal implantation results manifested that the bionic surface could encourage new endothelialization. This work provides an important reference for the construction of multifunction micro-environment on the cardiovascular scaffold surface.
Publisher
Springer US,Springer Nature B.V
Subject
/ Biomedical Engineering and Bioengineering
/ Bionics
/ Ceramics
/ Chemistry and Materials Science
/ Collagen
/ Collagen Type IV - chemistry
/ Collagen Type IV - physiology
/ Dogs
/ Endothelial Cells - physiology
/ Glass
/ Heparins
/ Humans
/ Microscopy, Electron, Scanning
/ Regenerative Medicine/Tissue Engineering
/ Staining
/ Stents
