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Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles
by
Gray, Joe W
, Liu, Gang L
, Wang, Xueding
, Anwar, M. Sabieh
, Hann, Byron
, Xie, Z. Harry
, Chen, Fanqing Frank
, Bouchard, Louis-S
, Pines, Alexander
in
absorption
/ biocompatibility
/ Biological Sciences
/ Cobalt
/ Diagnostic Imaging - methods
/ Electromagnetic absorption
/ Gels
/ Gold
/ image analysis
/ Imaging
/ Magnetic resonance imaging
/ Magnetic Resonance Imaging - methods
/ Metal Nanoparticles
/ Nanoparticles
/ Nanorods
/ Nanotechnology
/ NMR
/ Nuclear magnetic resonance
/ Physical Sciences
/ Sensitivity and Specificity
/ tissues
/ Tomography
/ Tomography - methods
/ Wavelengths
2009
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Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles
by
Gray, Joe W
, Liu, Gang L
, Wang, Xueding
, Anwar, M. Sabieh
, Hann, Byron
, Xie, Z. Harry
, Chen, Fanqing Frank
, Bouchard, Louis-S
, Pines, Alexander
in
absorption
/ biocompatibility
/ Biological Sciences
/ Cobalt
/ Diagnostic Imaging - methods
/ Electromagnetic absorption
/ Gels
/ Gold
/ image analysis
/ Imaging
/ Magnetic resonance imaging
/ Magnetic Resonance Imaging - methods
/ Metal Nanoparticles
/ Nanoparticles
/ Nanorods
/ Nanotechnology
/ NMR
/ Nuclear magnetic resonance
/ Physical Sciences
/ Sensitivity and Specificity
/ tissues
/ Tomography
/ Tomography - methods
/ Wavelengths
2009
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Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles
by
Gray, Joe W
, Liu, Gang L
, Wang, Xueding
, Anwar, M. Sabieh
, Hann, Byron
, Xie, Z. Harry
, Chen, Fanqing Frank
, Bouchard, Louis-S
, Pines, Alexander
in
absorption
/ biocompatibility
/ Biological Sciences
/ Cobalt
/ Diagnostic Imaging - methods
/ Electromagnetic absorption
/ Gels
/ Gold
/ image analysis
/ Imaging
/ Magnetic resonance imaging
/ Magnetic Resonance Imaging - methods
/ Metal Nanoparticles
/ Nanoparticles
/ Nanorods
/ Nanotechnology
/ NMR
/ Nuclear magnetic resonance
/ Physical Sciences
/ Sensitivity and Specificity
/ tissues
/ Tomography
/ Tomography - methods
/ Wavelengths
2009
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Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles
Journal Article
Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles
2009
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Overview
Multimodality imaging based on complementary detection principles has broad clinical applications and promises to improve the accuracy of medical diagnosis. This means that a tracer particle advantageously incorporates multiple functionalities into a single delivery vehicle. In the present work, we explore a unique combination of MRI and photoacoustic tomography (PAT) to detect picomolar concentrations of nanoparticles. The nanoconstruct consists of ferromagnetic (Co) particles coated with gold (Au) for biocompatibility and a unique shape that enables optical absorption over a broad range of frequencies. The end result is a dual-modality probe useful for the detection of trace amounts of nanoparticles in biological tissues, in which MRI provides volume detection, whereas PAT performs edge detection.
Publisher
National Academy of Sciences,National Acad Sciences
Subject
/ Cobalt
/ Diagnostic Imaging - methods
/ Gels
/ Gold
/ Imaging
/ Magnetic Resonance Imaging - methods
/ Nanorods
/ NMR
/ tissues
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