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rmlA gene encoding d-glucose-1-phosphate thymidylyltransferase is essential for mycobacterial growth

by Ma, Yufang , Xin, Yi , Qu, Hong , Dong, Xu

in Arabinogalactan / arabinogalactans / bacteria / Bacterial Proteins / Bacterial Proteins - genetics / Bacterial Proteins - metabolism / Bacteriology / Biogenesis of cell structures, supramolecular organization / Biological and medical sciences / Biosynthesis / cell biology / Cell morphology / Cytology / d-glucose-1-phosphate thymidylyltransferase / Disaccharides / Drug development / drugs / dTDP-rhamnose / enzymes / enzymology / Fundamental and applied biological sciences. Psychology / Gene Deletion / Gene Expression Regulation, Bacterial / genes / Genes, Bacterial / Genes, Essential / genetics / Glucose / Glucose-1-phosphate / Glucose-1-phosphate thymidylyltransferase / growth & development / Homologous recombination / Homology / Humans / metabolism / Microbiology / Microscopy, Electron, Scanning / Morphology / mutants / mycobacterial cell wall / Mycobacterium smegmatis / Mycobacterium smegmatis - enzymology / Mycobacterium smegmatis - genetics / Mycobacterium smegmatis - growth & development / Mycobacterium smegmatis - ultrastructure / Mycobacterium tuberculosis / Mycobacterium tuberculosis - enzymology / Mycobacterium tuberculosis - genetics / Mycobacterium tuberculosis - growth & development / Nucleotidyltransferases / Nucleotidyltransferases - genetics / Nucleotidyltransferases - metabolism / Peptidoglycans / Plasmids / Plasmids - genetics / Recombination, Genetic / Rhamnose / rmlA / RmlA gene / ultrastructure

2007

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rmlA gene encoding d-glucose-1-phosphate thymidylyltransferase is essential for mycobacterial growth

by Ma, Yufang , Xin, Yi , Qu, Hong , Dong, Xu

2007

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rmlA gene encoding d-glucose-1-phosphate thymidylyltransferase is essential for mycobacterial growth

by Ma, Yufang , Xin, Yi , Qu, Hong , Dong, Xu

2007

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Journal Article

rmlA gene encoding d-glucose-1-phosphate thymidylyltransferase is essential for mycobacterial growth

Ma, Yufang,

Xin, Yi,

Qu, Hong,

Dong, Xu

2007

Overview

The rhamnose-GlcNAc disaccharide is a critical linker which connects arabinogalactan to peptidoglycan via a phosphodiester linkage. The biosynthesis of dTDP-rhamnose is catalysed by four enzymes, and the first reaction is catalysed by an rmlA gene encoding d-glucose-1-phosphate thymidylyltransferase (RmlA). We generated a Mycobacterium smegmatis mc²155 mutant lacking the rmlA gene via a homologous recombination method. We tested the requirement for the rmlA gene and the effect of a lack of RmlA on bacterial cell morphology. The results demonstrate that the rmlA gene is essential for mycobacterial growth and that lack of RmlA activity has profound negative effects on bacterial cell morphology. RmlA is thus a potential target for the development of new antituberculosis drugs.

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Publisher

Oxford, UK : Blackwell Publishing Ltd,Blackwell Publishing Ltd,Blackwell,Oxford University Press

Subject

/ Bacterial Proteins - genetics

/ Bacterial Proteins - metabolism

/ Bacteriology