Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Immunogenetic Predisposition to SARS-CoV-2 Infection

by Lehmann, Claudia , Enczmann, Juergen , Lakowa, Nicole , Doxiadis, Ilias , Loeffler-Wirth, Henry , Balz, Vera , Gruenewald, Thomas , Landgraf, Ramona , Fischer, Johannes C.

in ABO system / Antigens / Bar codes / Blood groups / Blood platelets / classical HLA / Coronaviruses / COVID-19 / Dengue fever / DQA1 protein / Drb1 protein / Hepatitis / Histocompatibility antigen HLA / homozygosity / HPA / Immune system / Immunogenetics / Immunology / Infections / Major histocompatibility complex / MHC / Next-generation sequencing / Nobel prizes / non-classical HLA / Pathogens / Peptides / Phenotypes / Platelets / Severe acute respiratory syndrome coronavirus 2 / Software / Vaccination / Viral infections

2022

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Immunogenetic Predisposition to SARS-CoV-2 Infection

by Lehmann, Claudia , Enczmann, Juergen , Lakowa, Nicole , Doxiadis, Ilias , Loeffler-Wirth, Henry , Balz, Vera , Gruenewald, Thomas , Landgraf, Ramona , Fischer, Johannes C.

2022

Confirm

Do you wish to request the book?

Immunogenetic Predisposition to SARS-CoV-2 Infection

by Lehmann, Claudia , Enczmann, Juergen , Lakowa, Nicole , Doxiadis, Ilias , Loeffler-Wirth, Henry , Balz, Vera , Gruenewald, Thomas , Landgraf, Ramona , Fischer, Johannes C.

2022

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Immunogenetic Predisposition to SARS-CoV-2 Infection

Lehmann, Claudia,

Enczmann, Juergen,

Lakowa, Nicole,

Doxiadis, Ilias,

Loeffler-Wirth, Henry,

Balz, Vera,

Gruenewald, Thomas,

Landgraf, Ramona,

Fischer, Johannes C.

2022

Overview

Herein, we included 527 individuals from two Hospitals, Chemnitz and University-Hospital Leipzig. In total, 199 were negative for PCR and 328 were positive upon first admission. We used next generation sequencing for HLA-A, B, C, DRB1, DRB345, DQA1, DQB1, DPA1, and DPB1, and in some cases, HLA-E, F, G, and H. Furthermore, we molecularly defined 22 blood group systems comprising 26 genes and 5 platelet antigen genes. We observed a significant enrichment of homozygosity for DQA/DQB in the positive group. Within the negative subjects, HLA-B*57:01, HLA-B*55:01, DRB1*13:01, and DRB1*01:01 were enriched, and in the positive group, homozygosity for DQA/DQB, DRB1*09:01, and DRB1*15:01 was observed. DQA1*01:01, DQA1*02:01, and DQA1*01:03 were enriched in the negative group. HLA-DQB1*06:02 was enriched in the positive group, and HLA-DQB1*05:01 and HLA-DQB1*06:03 were enriched in the negative group. For the blood group systems MNS, RH, LE, FY, JK, YT, DO, and KN, enrichment was seen in both groups, depending on the antigen under observation. Homozygosity for D-positive RHD alleles, as well as the phenotypes M-N+ of the MNS blood group system and Yk(a-) of the KN system, were enriched in the positive group. All of these significances disappeared upon correction. Subjects who carried homozygous HPA-1a were more frequent in the negative group, contrasting with the finding that HPA-1ab was enriched in the positive group.

Share this book

Add to My Shelf

Publisher

MDPI AG,MDPI

Subject