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Quality of Life and the Effect of Memantine in Dementia with Lewy Bodies and Parkinson’s Disease Dementia
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Quality of Life and the Effect of Memantine in Dementia with Lewy Bodies and Parkinson’s Disease Dementia
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Journal Article
Quality of Life and the Effect of Memantine in Dementia with Lewy Bodies and Parkinson’s Disease Dementia
2011
Overview
Aim: To investigate quality of life (QOL) and the effect of memantine treatment in patients with Lewy body dementias. Methods: A secondary analysis of a randomized controlled study in 70 patients with Parkinson’s disease dementia (PDD) or dementia with Lewy bodies (DLB) over 24 weeks using caregiver-rated QOL-Alzheimer’s disease (AD) in domains according to the WHO’s classification of health. Results: Baseline QOL shows lower ratings for body functions over environmental factors in DLB/PDD. Treatment with memantine significantly improves life as a whole compared to placebo and improves total QOL, body function and structure. Conclusion: This study shows that memantine improves QOL in Lewy body dementias. We also demonstrate important QOL patterns which can be used in clinical practice.
Publisher
Karger,S. Karger AG
Subject
/ Antiparkinson Agents - therapeutic use
/ Antipsychotic Agents - administration & dosage
/ Antipsychotic Agents - therapeutic use
/ Biological and medical sciences
/ Dementia
/ Diagnostic and Statistical Manual of Mental Disorders
/ Disease
/ Factor Analysis, Statistical
/ Female
/ Humans
/ Levodopa - administration & dosage
/ Lewy Body Disease - drug therapy
/ Lewy Body Disease - psychology
/ Male
/ Parkinson Disease - complications
/ Parkinson Disease - drug therapy
/ Parkinson Disease - psychology
/ Patients
/ Vascular diseases and vascular malformations of the nervous system
