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RACK1, a versatile hub in cancer
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Journal Article
RACK1, a versatile hub in cancer
2015
Overview
RACK1 is a highly conserved intracellular adaptor protein with significant homology to Gβ and was originally identified as the anchoring protein for activated protein kinase C. In the past 20 years, the number of binding partners and validated cellular functions for RACK1 has increased, which facilitates clarification of its involvement in different biological events. In this review, we will focus on its role in cancer, summarizing its aberrant expression, pro- or anti-oncogenic effects and the underlying mechanisms in various cancers.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 631/67
/ 82/51
/ 82/80
/ 96/95
/ Animals
/ Cancer
/ GTP-Binding Proteins - genetics
/ GTP-Binding Proteins - metabolism
/ Homology
/ Humans
/ Kinases
/ Medicine
/ Neoplasm Proteins - genetics
/ Neoplasm Proteins - metabolism
/ Oncology
/ Proteins
/ Receptors for Activated C Kinase
/ Receptors, Cell Surface - genetics
/ Receptors, Cell Surface - metabolism
/ review
