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Urocortin stimulates the ERK1/2 signaling pathway and the proliferation of HeLa cells via CRF receptor 1
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Urocortin stimulates the ERK1/2 signaling pathway and the proliferation of HeLa cells via CRF receptor 1
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Journal Article
Urocortin stimulates the ERK1/2 signaling pathway and the proliferation of HeLa cells via CRF receptor 1
2023
Overview
Corticotropin‐releasing factor (CRF) stimulates adrenocorticotropic hormone (ACTH) secretion from the pituitary gland and is an essential regulator of the hypothalamic–pituitary–adrenocortical axis. Isoforms of CRF receptor are known to mediate the effects of urocortin stress ligands on the regulation of stress responses, anxiety, and feeding behavior; however, urocortin stress ligands also influence cell proliferation. In view of the tumor‐promoting capacity of prolonged stress, here we investigated (a) the effect of urocortin on cell proliferative signaling via extracellular signal‐regulated kinase 1/2, (b) the expression and cellular distribution of the specific CRF receptor isoforms, and (c) the intracellular localization of phosphorylated ERK1/2 in HeLa cells. Stimulation of cell proliferation was observed in the presence of 10 nm urocortin. Our data also suggest that MAP kinase MEK, the transcription factors E2F‐1 and p53, and PKB/Akt are involved in this process. These findings may have therapeutic relevance for the targeted treatment of various malignancies. We investigated the signaling and biological effects of human urocortin 1 (hUCN1) in HeLa cells. hUCN1 treatment stimulates ERK1/2 MAPK phosphorylation, which is initiated by CRF1 and then mediated via MEK. The S‐phase gene‐activating transcription factor E2F‐1 is also induced, leading eventually to increased cell proliferation, as demonstrated by MTT assay.
Publisher
John Wiley & Sons, Inc,John Wiley and Sons Inc,Wiley
Subject
/ anxiety
/ Cancer
/ Corticotropin-releasing hormone
/ Corticotropin-Releasing Hormone - metabolism
/ Corticotropin-Releasing Hormone - pharmacology
/ E2F‐1
/ Extracellular signal-regulated kinase
/ Glycerol
/ HeLa
/ Humans
/ Isoforms
/ Kinases
/ Ligands
/ mitogen-activated protein kinase
/ Peptides
/ Proteins
/ Receptors, Corticotropin-Releasing Hormone - metabolism
/ Software
