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Melatonin Ameliorates Coxsackievirus B3-Induced Myocarditis by Regulating Apoptosis and Autophagy

by Gu, Xiaohong , Xia, Tianhe , Ge, Lisha , Rong, Xing , Wu, Tingting , Sang, Yimiao , Li, Yuechun , Pan, Lulu , Zhang, Chunxiang , Zhang, Yuanhai , Chu, Maoping

in Antibodies / Apoptosis / Autophagy / Cell death / coxsackievirus B3 / Coxsackieviruses / Edema / Heart / Heart diseases / Ischemia / Laboratory animals / Melatonin / Myocarditis / Pharmacology / Pineal gland / Proteins / Tumor necrosis factor-TNF / Variance analysis / Viruses

2018

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Melatonin Ameliorates Coxsackievirus B3-Induced Myocarditis by Regulating Apoptosis and Autophagy

by Gu, Xiaohong , Xia, Tianhe , Ge, Lisha , Rong, Xing , Wu, Tingting , Sang, Yimiao , Li, Yuechun , Pan, Lulu , Zhang, Chunxiang , Zhang, Yuanhai , Chu, Maoping

2018

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Melatonin Ameliorates Coxsackievirus B3-Induced Myocarditis by Regulating Apoptosis and Autophagy

by Gu, Xiaohong , Xia, Tianhe , Ge, Lisha , Rong, Xing , Wu, Tingting , Sang, Yimiao , Li, Yuechun , Pan, Lulu , Zhang, Chunxiang , Zhang, Yuanhai , Chu, Maoping

2018

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Journal Article

Melatonin Ameliorates Coxsackievirus B3-Induced Myocarditis by Regulating Apoptosis and Autophagy

Gu, Xiaohong,

Xia, Tianhe,

Ge, Lisha,

Rong, Xing,

Wu, Tingting,

Sang, Yimiao,

Li, Yuechun,

Pan, Lulu,

Zhang, Chunxiang,

Zhang, Yuanhai,

Chu, Maoping

2018

Overview

Current therapeutics options for viral myocarditis are unsatisfactory. Melatonin (MLT), a hormone secreted by the pineal gland and other organs, has protective effects on ischemic heart injury. However, the potential therapeutic effect of MLT on viral myocarditis is unknown. In this study, we investigated the protective effect of MLT on viral myocarditis in a mouse model of myocarditis infected with coxsackievirus B3 (CVB3) and explored the probable mechanisms. Mice with CVB3-induced myocarditis displayed inflammatory cell infiltration and interstitial edema. MLT treatment significantly ameliorated the myocardial injuries. In addition, the rate of autophagy changed, although apoptosis was inhibited in mouse hearts following treatment with MLT. These results suggest that MLT has a strong therapeutic effect on acute viral myocarditis, which is associated with changes in autophagy and apoptosis in the heart. Thus, MLT could be a promising novel therapeutic approach against viral myocarditis.

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Publisher

Frontiers Media SA,Frontiers Media S.A

Subject

/ Edema