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Pneumococcal Vaccine Breakthrough and Failure in Infants and Children: A Narrative Review
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Pneumococcal Vaccine Breakthrough and Failure in Infants and Children: A Narrative Review
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Journal Article
Pneumococcal Vaccine Breakthrough and Failure in Infants and Children: A Narrative Review
2023
Overview
Globally, Streptococcus pneumoniae is a leading cause of vaccine-preventable morbidity and mortality in infants and children. In recent decades, large-scale pediatric immunization programs have substantially reduced the incidence of invasive pneumococcal disease. Despite this, residual vaccine-type pneumococcal disease remains in the form of vaccine breakthrough and vaccine failure. This targeted literature review aims to discuss aspects of vaccine breakthrough and failure in infants and children, including disease epidemiology, clinical presentation, risk factors, vaccination schedules, vaccine serotypes, correlates of protection, comorbidities, disease surveillance, and potential implications for future vaccine development.
