Journal Article

Temporal Statistical Relationship between Regional Cerebral Oxygen Saturation (rSO2) and Brain Tissue Oxygen Tension (PbtO2) in Moderate-to-Severe Traumatic Brain Injury: A Canadian High Resolution-TBI (CAHR-TBI) Cohort Study

Yang, Eleen, Griesdale, Donald, Kramer, Andreas H., Gomez, Alwyn, Aries, Marcel, Gallagher, Clare, Froese, Logan, Raj, Rahul, Thelin, Eric P., Bernard, Francis, Zeiler, Frederick A.

2023

Overview

Brain tissue oxygen tension (PbtO2) has emerged as a cerebral monitoring modality following traumatic brain injury (TBI). Near-infrared spectroscopy (NIRS)-based regional cerebral oxygen saturation (rSO2) can non-invasively examine cerebral oxygen content and has the potential for high spatial resolution. Past studies examining the relationship between PbtO2 and NIRS-based parameters have had conflicting results with varying degrees of correlation. Understanding this relationship will help guide multimodal monitoring practices and impact patient care. The aim of this study is to examine the relationship between PbtO2 and rSO2 in a cohort of TBI patients by leveraging contemporary statistical methods. A multi-institutional retrospective cohort study of prospectively collected data was performed. Moderate-to-severe adult TBI patients were included with concurrent rSO2 and PbtO2 monitoring during their stay in the intensive care unit (ICU). The high-resolution data were analyzed utilizing time series techniques to examine signal stationarity as well as the cross-correlation relationship between the change in PbtO2 and the change in rSO2 signals. Finally, modeling of the change in PbtO2 by the change in rSO2 was attempted utilizing linear methods that account for the autocorrelative nature of the data signals. A total of 20 subjects were included in the study. Cross-correlative analysis found that changes in PbtO2 were most significantly correlated with changes in rSO2 one minute earlier. Through mixed-effects and time series modeling of parameters, changes in rSO2 were found to often have a statistically significant linear relationship with changes in PbtO2 that occurred a minute later. However, changes in rSO2 were inadequate to predict changes in PbtO2. In this study, changes in PbtO2 were found to correlate most with changes in rSO2 approximately one minute earlier. While changes in rSO2 were found to contain information about future changes in PbtO2, they were not found to adequately model them. This strengthens the body of literature indicating that NIRS-based rSO2 is not an adequate substitute for PbtO2 in the management of TBI.

• Publisher: MDPI AG,MDPI
• Subject: Bioengineering / Brain / Brain research / brain tissue oxygen tension / Cohort analysis / Collaboration / Coma / Cross correlation / Data analysis / Data collection / Head injuries / High resolution / Infrared spectra / Infrared spectroscopy / Intensive care / Linear algebra / Mathematical models / Modelling / Monitoring / multimodal monitoring / Near infrared radiation / near-infrared spectroscopy / Observational studies / Oxygen / Oxygen content / Oxygen saturation / Oxygen tension / Parameters / Patients / regional cerebral oxygen saturation / Software / Spatial discrimination / Spatial resolution / Statistical analysis / Statistical methods / Statistics / Time series / Traumatic brain injury