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Bright-light intervention induces a dose-dependent increase in striatal response to risk in healthy volunteers
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Bright-light intervention induces a dose-dependent increase in striatal response to risk in healthy volunteers
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Bright-light intervention induces a dose-dependent increase in striatal response to risk in healthy volunteers
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Journal Article
Bright-light intervention induces a dose-dependent increase in striatal response to risk in healthy volunteers
2016
Overview
Bright-light interventions have successfully been used to reduce depression symptoms in patients with seasonal affective disorder, a depressive disorder most frequently occurring during seasons with reduced daylight availability. Yet, little is known about how light exposure impacts human brain function, for instance on risk taking, a process affected in depressive disorders.
Here we examined the modulatory effects of bright-light exposure on brain activity during a risk-taking task. Thirty-two healthy male volunteers living in the greater Copenhagen area received 3weeks of bright-light intervention during the winter season. Adopting a double-blinded dose-response design, bright-light was applied for 30minutes continuously every morning. The individual dose varied between 100 and 11.000lx. Whole-brain functional MRI was performed before and after bright-light intervention to probe how the intervention modifies risk-taking related neural activity during a two-choice gambling task. We also assessed whether inter-individual differences in the serotonin transporter-linked polymorphic region (5-HTTLPR) genotype influenced the effects of bright-light intervention on risk processing.
Bright-light intervention led to a dose-dependent increase in risk-taking in the LA/LA group relative to the non-LA/LA group. Further, bright-light intervention enhanced risk-related activity in ventral striatum and head of caudate nucleus in proportion with the individual bright-light dose. The augmentation effect of light exposure on striatal risk processing was not influenced by the 5-HTTLPR-genotype.
This study provides novel evidence that in healthy non-depressive individuals bright-light intervention increases striatal processing to risk in a dose-dependent fashion. The findings provide converging evidence that risk processing is sensitive to bright-light exposure during winter.
•Exposure to bright light may reduce depressive symptoms.•A 3-week bright-light intervention increased striatal response to risky choices.•Changes in risk-taking behavior post-intervention were determined by 5-HTTLPR status.
Publisher
Elsevier Inc,Elsevier Limited
Subject
Adaptation, Physiological - physiology
/ Adaptation, Physiological - radiation effects
/ Adult
/ Choice Behavior - physiology
/ Choice Behavior - radiation effects
/ Corpus Striatum - physiology
/ Corpus Striatum - radiation effects
/ Dose-Response Relationship, Radiation
/ Emotions
/ Humans
/ Light
/ Male
/ Photic Stimulation - methods
/ Winter
