Journal Article

Enhancing Therapy Adherence: Impact on Clinical Outcomes, Healthcare Costs, and Patient Quality of Life

Borowska, Mariola, Ostrowski, Janusz, Requena, Pilar, Religioni, Urszula, Barrios-Rodríguez, Rocío

2025

Overview

Adherence to therapy, defined as the extent to which a patient follows prescribed therapeutic recommendations, is a pivotal factor in the effective management of chronic diseases such as diabetes, hypertension, and cardiovascular conditions. This review highlights the profound influence of adherence on clinical outcomes, healthcare costs, and patient quality of life. Despite its critical importance, non-adherence remains a pervasive challenge globally, contributing to suboptimal treatment results, higher rates of complications, increased hospitalizations, and substantial healthcare expenditures. This narrative review examines the multifaceted impact of adherence, focusing on its role in achieving clinical efficacy, mitigating economic burdens, and enhancing patient well-being. The findings reveal that poor adherence exacerbates the risk of disease progression, complications, and higher healthcare costs. Conversely, improved adherence promotes better disease control, fewer complications, and enhanced patient quality of life. Interventions such as patient education, streamlined treatment regimens, and the integration of digital health tools have shown promise in addressing adherence barriers. Furthermore, the role of healthcare professionals is underscored as fundamental, with their continuous support, effective communication, and efforts to build patient trust being essential to fostering better adherence. In conclusion, adherence significantly affects clinical outcomes, healthcare costs, and patient quality of life. Addressing barriers to adherence requires a comprehensive and personalized approach, considering individual patient needs and circumstances. Future research should prioritize the long-term evaluation of emerging technologies and the development of tailored strategies to improve adherence across diverse patient populations. Strengthening adherence is not only crucial for individual patient outcomes, but also for enhancing the sustainability and efficiency of healthcare systems.

• Publisher: MDPI AG,MDPI
• Subject: adherence / Antihypertensive drugs / Blood pressure / Cardiovascular disease / Chronic diseases / Chronic illnesses / clinical efficacy / Clinical outcomes / Costs / Development and progression / Diabetes / Diabetes therapy / Economic aspects / Health care access / Health Care Costs - statistics & numerical data / Health care expenditures / Health care reform / healthcare costs / Heart attacks / Heart failure / Humans / Hypertension / Kidney diseases / Lifestyles / Low income groups / Medical care, Cost of / Medical personnel / Medical research / Medication Adherence - psychology / Medicine, Experimental / Mortality / Patient compliance / Patient education / Patient outcomes / Quality of life / Quality of Life - psychology / Questionnaires / Review / Side effects / Socioeconomic factors / Type 2 diabetes