Asset Details
Do you wish to reserve the book?
The role of the prostate in male fertility, health and disease
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The role of the prostate in male fertility, health and disease
Do you wish to request the book?
The role of the prostate in male fertility, health and disease
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The role of the prostate in male fertility, health and disease
2016
Overview
Key Points
Male fertility is controlled by a Zn
2+
-dependent short circuit of the Krebs cycle within prostate epithelial cells
Homeostasis of the prostate epithelium is reliant on the intracellular androgen-dependent accumulation of Zn
2+
and citrate
Sperm motility requires the coordinated action of the components of the two main fluids in the human seminal plasma: the prostatic fluid, which is enriched with Zn
2+
, citrate and kallikreins, and the semenogelin-enriched seminal vesicle secretion
The prostate is the direct target for a number of benign and malignant diseases that are potentially linked to impaired fertility status
Prostatitis might be directly linked with changes in fertility
The prostate gland is the major male reproductive gland involved in male fertility. In this Review, the authors discuss the reproductive function of the prostate gland, summarizing physiological and molecular mechanisms that connect prostate homeostasis with male fertility and describing how these mechanisms are associated with prostatic diseases. They highlight the central role of Zn
2+
and citrate in regulating activities of the prostate epithelium, discuss the influence of bacteria-related prostate inflammation on male fertility, and note the potential role of prostatic inflammation in the development of prostatic hyperplastic growth and prostate carcinogenesis.
Ejaculation is a synchronized cascade of events that has the ultimate goal of activating sperm and enabling them to reach an egg for fertilization. The seminal plasma contains a complex mixture of fluids that is secreted from the testes, epididymis and male accessory glands. The prostate gland has a pivotal role in this process, as prostatic fluid enriched in Zn
2+
, citrate and kallikreins is crucial for the molecular synchronization of the functional cascade triggered by ejaculatory stimuli. The prostate is the target of a number of common diseases that can affect male fertility at different ages. In both young and aged men, prostatic diseases or an unhealthy prostate can affect spermatozoa functioning and, therefore, male fertility. Consideration of prostate physiology emphasizes a number of points: the central role of Zn
2+
and citrate in the regulation of prostate epithelium homeostasis and in ejaculation; the influence of bacteria-related prostatic inflammation on male fertility; and the potential role of prostatic inflammation in promoting the development of prostatic hyperplastic growth and carcinogenesis.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Analysis
/ Animals
/ Bacteria
/ Humans
/ Infertility, Male - diagnosis
/ Infertility, Male - physiopathology
/ Male
/ Plasma
/ Prostate
/ Prostatic Neoplasms - diagnosis
/ Prostatic Neoplasms - physiopathology
/ Prostatic Neoplasms - therapy
/ Prostatitis - physiopathology
/ Sperm
/ Testes
/ Urology
