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Isolation and Characterization of Aphidicolin Derivatives from Tolypocladium inflatum
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Isolation and Characterization of Aphidicolin Derivatives from Tolypocladium inflatum
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Journal Article
Isolation and Characterization of Aphidicolin Derivatives from Tolypocladium inflatum
2017
Overview
Inflatin G (1), a new aphidicolin analogue, together with seven known compounds inflatin A (2), inflatin B (3), aphidicolin (4), aphidicolin-17-monoacetate (5), gulypyrone A (6), pyridoxatin rotamers A (7) and B (8), were isolated from the ascomycete fungus Tolypocladium inflatum. Their structures were determined through NMR analyses and the circular dichroism data of the in situ formed [Rh2(OCOCF3)4] complexes. Compounds 1, 4, 5, 7, and 8 showed modest cytotoxicity against four human cancer cell lines A549, CNE1-MP1, A375, and MCF-7.
Publisher
MDPI AG,MDPI
