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Biosynthesis of nearly monodispersed poly(ε-l-lysine) in Streptomyces species
by
Hirohara, Hideo
, Kataoka, Kazuma
, Takehara, Munenori
, Mizukami, Shinya
, Saimura, Masayuki
in
Amino acids
/ Applied Microbiology
/ Biochemistry
/ biodegradability
/ Biodegradation
/ Biological and medical sciences
/ Biomedical and Life Sciences
/ Biosynthesis
/ Biotechnology
/ cell growth
/ Cells
/ Culture Media
/ Fermentation
/ Fundamental and applied biological sciences. Psychology
/ hydrolases
/ Hydrolases - metabolism
/ Life Sciences
/ Microbiology
/ Polylysine - biosynthesis
/ Polylysine - chemistry
/ polymerization
/ Polymers
/ Review
/ Streptomyces
/ Streptomyces - enzymology
/ Streptomyces - growth & development
/ Streptomyces - metabolism
2008
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Biosynthesis of nearly monodispersed poly(ε-l-lysine) in Streptomyces species
by
Hirohara, Hideo
, Kataoka, Kazuma
, Takehara, Munenori
, Mizukami, Shinya
, Saimura, Masayuki
in
Amino acids
/ Applied Microbiology
/ Biochemistry
/ biodegradability
/ Biodegradation
/ Biological and medical sciences
/ Biomedical and Life Sciences
/ Biosynthesis
/ Biotechnology
/ cell growth
/ Cells
/ Culture Media
/ Fermentation
/ Fundamental and applied biological sciences. Psychology
/ hydrolases
/ Hydrolases - metabolism
/ Life Sciences
/ Microbiology
/ Polylysine - biosynthesis
/ Polylysine - chemistry
/ polymerization
/ Polymers
/ Review
/ Streptomyces
/ Streptomyces - enzymology
/ Streptomyces - growth & development
/ Streptomyces - metabolism
2008
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Biosynthesis of nearly monodispersed poly(ε-l-lysine) in Streptomyces species
by
Hirohara, Hideo
, Kataoka, Kazuma
, Takehara, Munenori
, Mizukami, Shinya
, Saimura, Masayuki
in
Amino acids
/ Applied Microbiology
/ Biochemistry
/ biodegradability
/ Biodegradation
/ Biological and medical sciences
/ Biomedical and Life Sciences
/ Biosynthesis
/ Biotechnology
/ cell growth
/ Cells
/ Culture Media
/ Fermentation
/ Fundamental and applied biological sciences. Psychology
/ hydrolases
/ Hydrolases - metabolism
/ Life Sciences
/ Microbiology
/ Polylysine - biosynthesis
/ Polylysine - chemistry
/ polymerization
/ Polymers
/ Review
/ Streptomyces
/ Streptomyces - enzymology
/ Streptomyces - growth & development
/ Streptomyces - metabolism
2008
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Biosynthesis of nearly monodispersed poly(ε-l-lysine) in Streptomyces species
Journal Article
Biosynthesis of nearly monodispersed poly(ε-l-lysine) in Streptomyces species
2008
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Overview
Poly(ε-
l
-lysine) (ε-PL) is a naturally occurring poly(amino acid) characterized by a unique structure linking ε-amino and carboxyl groups of
l
-lysine. Due to its various functions and its biodegradability and non-toxicity, the ε-PL polymer has attracted increasing attention in recent years. ε-PL is frequently found in various strains of
Streptomyces
sp. This review gives an up-to-date overview regarding the biosynthesis of ε-PL focussing mainly on results obtained from ten newly isolated producer strains, using the two-stage culture method of cell growth and ε-PL production cultures. The production of nearly monodispersed ε-PL is covered together with the development of ε-PL specific hydrolases and the release of synthesized ε-PL into the culture broth. From these results, coupled with the termination of polymerization through nucleophilic chain transfer, the biosynthetic mechanism of the polymer is discussed.
Publisher
Springer Netherlands,Springer,Springer Nature B.V
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