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Biosynthesis of nearly monodispersed poly(ε-l-lysine) in Streptomyces species
Biosynthesis of nearly monodispersed poly(ε-l-lysine) in Streptomyces species
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Biosynthesis of nearly monodispersed poly(ε-l-lysine) in Streptomyces species
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Biosynthesis of nearly monodispersed poly(ε-l-lysine) in Streptomyces species
Biosynthesis of nearly monodispersed poly(ε-l-lysine) in Streptomyces species

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Biosynthesis of nearly monodispersed poly(ε-l-lysine) in Streptomyces species
Biosynthesis of nearly monodispersed poly(ε-l-lysine) in Streptomyces species
Journal Article

Biosynthesis of nearly monodispersed poly(ε-l-lysine) in Streptomyces species

2008
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Overview
Poly(ε- l -lysine) (ε-PL) is a naturally occurring poly(amino acid) characterized by a unique structure linking ε-amino and carboxyl groups of l -lysine. Due to its various functions and its biodegradability and non-toxicity, the ε-PL polymer has attracted increasing attention in recent years. ε-PL is frequently found in various strains of Streptomyces sp. This review gives an up-to-date overview regarding the biosynthesis of ε-PL focussing mainly on results obtained from ten newly isolated producer strains, using the two-stage culture method of cell growth and ε-PL production cultures. The production of nearly monodispersed ε-PL is covered together with the development of ε-PL specific hydrolases and the release of synthesized ε-PL into the culture broth. From these results, coupled with the termination of polymerization through nucleophilic chain transfer, the biosynthetic mechanism of the polymer is discussed.