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Effects of transdermal nicotine on episodic memory in non-smokers with and without schizophrenia
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Effects of transdermal nicotine on episodic memory in non-smokers with and without schizophrenia
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Effects of transdermal nicotine on episodic memory in non-smokers with and without schizophrenia
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Journal Article
Effects of transdermal nicotine on episodic memory in non-smokers with and without schizophrenia
2008
Overview
Rationale
Nicotinic agonists may improve attention and memory in humans and may ameliorate some cognitive deficits associated with neuropsychiatric disorders such as schizophrenia.
Materials and methods
We investigated the effects of a single dose of nicotine on episodic memory performance in 10 adults with schizophrenia and 12 healthy controls. Participants were nonsmokers in order to avoid confounding effects of nicotine withdrawal and reinstatement on memory. At each of two study visits, participants performed a test of episodic memory before and 4 h after application of a 14-mg transdermal nicotine (or identical placebo) patch in counterbalanced order.
Results
Compared with placebo, nicotine treatment was associated with more rapid and accurate recognition of novel items. There was a trend for a treatment by diagnosis interaction, such that the effect of nicotine to reduce false alarms was stronger in the schizophrenia than the control group. There was no effect of nicotine on accuracy or reaction time for identification of previously viewed items.
Conclusions
These data suggest that nicotine improves novelty detection in non-smokers, an effect that may be more pronounced in non-smokers with schizophrenia. Because memory deficits are associated with functional impairment in schizophrenia and because impaired novelty detection has been linked to the positive symptoms of schizophrenia, study of the effects of chronic nicotinic agonist treatment on novelty detection may be warranted.
Publisher
Springer-Verlag,Springer,Springer Nature B.V
Subject
/ Adult
/ Adult and adolescent clinical studies
/ Biological and medical sciences
/ Biomedical and Life Sciences
/ Female
/ Humans
/ Male
/ Memory
/ Mental Recall - drug effects
/ Nicotine
/ Nicotine - administration & dosage
/ Psychology. Psychoanalysis. Psychiatry
/ Psychotic Disorders - drug therapy
/ Psychotic Disorders - psychology
/ Reaction Time - drug effects
