Journal Article

Potential marker subset of blood-circulating cytokines on hematopoietic progenitor-to-Th1 pathway in COVID-19

Inaba, Tohru, Nakano, Masakazu, Takashima, Yasuo, Ohta, Bon, Fujita, Naohisa, Yoshii, Kengo, Omi, Natsue, Sudo, Kazuki, Tashiro, Kei, Matsuyama, Tasuku, Nakaya, Takaaki, Tokuda, Yuichi, Sotozono, Chie, Matsumoto, Kazumichi, Sawa, Teiji, Tanaka, Masami

2024

Overview

In this study, we analyzed a relatively large subset of proteins, including 109 kinds of blood-circulating cytokines, and precisely described a cytokine storm in the expression level and the range of fluctuations during hospitalization for COVID-19. Of the proteins analyzed in COVID-19, approximately 70% were detected with Bonferroni-corrected significant differences in comparison with disease severity, clinical outcome, long-term hospitalization, and disease progression and recovery. Specifically, IP-10, sTNF-R1, sTNF-R2, sCD30, sCD163, HGF, SCYB16, IL-16, MIG, SDF-1, and fractalkine were found to be major components of the COVID-19 cytokine storm. Moreover, the 11 cytokines (i.e., SDF-1, SCYB16, sCD30, IL-11, IL-18, IL-8, IFN-γ, TNF-α, sTNF-R2, M-CSF, and I-309) were associated with the infection, mortality, disease progression and recovery, and long-term hospitalization. Increased expression of these cytokines could be explained in sequential pathways from hematopoietic progenitor cell differentiation to Th1-derived hyperinflammation in COVID-19, which might also develop a novel strategy for COVID-19 therapy with recombinant interleukins and anti-chemokine drugs.

• Publisher: Frontiers Media SA,Frontiers Media S.A
• Subject: blood-circulating cytokine / coefficient of variation / COVID-19 / Cytokine storm / Hospitals / Infections / Inflammation / Intensive care / Laboratories / Medicine / Patients / Sample size / Severe acute respiratory syndrome coronavirus 2 / Software / Steroids / timelapse monitoring / Tumor necrosis factor-TNF / Variance analysis