Journal Article

Causal relationship between mitochondrial proteins and risks of aortic aneurysms and aortic dissection: a Mendelian randomization study

Lin, Ziyan, Wu, Qingtong, Wang, Lei, Lin, Yuzuo, Chen, Liangwan, Zhong, Guodong

2025

Overview

Background Mitochondrial dysfunction may be linked to the development of aortic aneurysm (AA) and aortic dissection (AD). This study aimed to evaluate the potential associations between proteins related to mitochondrial function and the risks of AA/AD using Mendelian randomization (MR). Methods Large-scale publicly available genome-wide association studies (GWAS) and FinnGen summary data were utilized for MR analysis. The causal relationship between mitochondrial proteins and AA/AD was assessed using inverse-variance weighted (IVW) as the primary method. Sensitivity analyses were conducted to detect heterogeneity and pleiotropy by Cochran’s Q test, MR-Egger test, MR-PRESSO global test, and “leave-one-out” analysis. Results There were potential causal relationships between several mitochondrial proteins and AA/AD. Specifically, the iron-sulfur cluster assembly enzyme ISCU (OR = 1.165, 95% CI: 1.051–1.291, P  = 0.004) and NFU1 iron-sulfur cluster scaffold homolog (OR = 1.184, 95% CI: 1.056–1.329, P  = 0.004) were identified as potential risk factors for AA; whereas the 39 S ribosomal protein L14 (OR = 0.868, 95% CI: 0.764–0.987, P  = 0.031) was found to be a protective factor for AA. Furthermore, 39 S ribosomal protein L33 (OR = 1.134, 95% CI: 1.010–1.274, P  = 0.033) and cytochrome C oxidase subunit 5B (OR = 1.330, 95% CI: 1.037–1.706, P  = 0.025) were associated with increased risks of AD; whereas the 39 S ribosomal protein L52 (OR = 0.736, 95% CI: 0.550–0.984, P  = 0.038) and mitochondrial ubiquitin ligase activator of NFKB 1 (OR = 0.806, 95% CI: 0.656–0.989, P  = 0.039) were identified as potential protective factors for AD. Sensitivity analysis confirmed the stability of the results. Conclusions This study identified potential genetic associations between mitochondrial proteins and AA/AD. Targeting these mitochondrial proteins may help prevent the occurrence of AA/AD.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Advertising executives / Alzheimer's disease / Aorta / Aortic aneurysm / Aortic Aneurysm - genetics / Aortic aneurysms / Aortic dissection / Aortic Dissection - genetics / Apoptosis / Cardiac Surgery / Cell death / Clusters / Confounding (Statistics) / Cytochrome c / Cytochrome-c oxidase / Datasets / Disease prevention / Dissecting aneurysm / Dissection / Epidemiology / Extracellular matrix / Genetic Predisposition to Disease / Genome-wide association studies / Genome-Wide Association Study / Genomes / Genomics / Heterogeneity / Homeostasis / Humans / Inflammation / Iron / Iron compounds / Ligases / Medicine / Medicine & Public Health / Mendelian randomization / Mendelian Randomization Analysis - methods / Metabolism / Mitochondria / Mitochondrial DNA / Mitochondrial Proteins - genetics / Mitochondrial Proteins - metabolism / Mortality / NF-κB protein / Oxidases / Oxidative stress / Pathogenesis / Pleiotropy / Proteins / Randomization / Risk Factors / Sensitivity analysis / Smooth muscle / Sulfur / Sulfur compounds / Surgery / Thoracic Surgery / Ubiquitin-protein ligase / Variables