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FOXO1 inactivation induces cisplatin resistance in bladder cancer

by Yujiro Nagata , Hiroshi Miyamoto , Hiroki Ide , Taichi Mizushima , Alexander S. Baras , Takuro Goto , Satoshi Inoue , Guiyang Jiang , Eiji Kashiwagi , Yuki Teramoto

in Antineoplastic Agents / Antineoplastic Agents - pharmacology / Apoptosis / Bladder cancer / Cancer / Cancer therapies / Chemosensitization / Chemotherapy / Cisplatin / Cisplatin - pharmacology / Cytotoxicity / Drug Resistance, Neoplasm / Drug Resistance, Neoplasm - genetics / Forkhead Box Protein O1 / Forkhead Box Protein O1 - genetics / Forkhead Box Protein O1 - metabolism / FOXO1 protein / Gene Expression / Gene Silencing / Humans / Immunohistochemistry / Invasiveness / Kinases / Letter to the Editor / Letters to the Editor / Metastases / Tumors / Urinary bladder / Urinary Bladder Neoplasms / Urinary Bladder Neoplasms - drug therapy / Urinary Bladder Neoplasms - genetics / Urinary Bladder Neoplasms - metabolism

2020

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FOXO1 inactivation induces cisplatin resistance in bladder cancer

by Yujiro Nagata , Hiroshi Miyamoto , Hiroki Ide , Taichi Mizushima , Alexander S. Baras , Takuro Goto , Satoshi Inoue , Guiyang Jiang , Eiji Kashiwagi , Yuki Teramoto

2020

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FOXO1 inactivation induces cisplatin resistance in bladder cancer

by Yujiro Nagata , Hiroshi Miyamoto , Hiroki Ide , Taichi Mizushima , Alexander S. Baras , Takuro Goto , Satoshi Inoue , Guiyang Jiang , Eiji Kashiwagi , Yuki Teramoto

2020

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Journal Article

FOXO1 inactivation induces cisplatin resistance in bladder cancer

Yujiro Nagata,

Hiroshi Miyamoto,

Hiroki Ide,

Taichi Mizushima,

Alexander S. Baras,

Takuro Goto,

Satoshi Inoue,

Guiyang Jiang,

Eiji Kashiwagi,

Yuki Teramoto

2020

Overview

We found that FOXO1‐shRNA sublines or FOXO1‐positive cells co–treated with a FOXO1 inhibitor were significantly more resistant to cisplatin treatment at pharmacological concentrations, compared with respective control sublines or those with mock treatment. Western blot demonstrated considerable increases in the expression levels of a phosphorylated inactive form of FOXO1 (p‐FOXO1) in cisplatin‐resistant sublines established by long‐term culture with low/increasing doses of cisplatin, compared with respective controls. Immunohistochemistry in surgical specimens from patients with muscle‐invasive bladder cancer undergoing cisplatin‐based neoadjuvant therapy further showed a strong trend to associate between p‐FOXO1 positivity and unfavorable response to chemotherapy.

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Publisher

Wiley,John Wiley & Sons, Inc,John Wiley and Sons Inc

Subject

Antineoplastic Agents

/ Antineoplastic Agents - pharmacology

/ Cancer