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Control of Local Protein Synthesis and Initial Events in Myelination by Action Potentials
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Control of Local Protein Synthesis and Initial Events in Myelination by Action Potentials
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Journal Article
Control of Local Protein Synthesis and Initial Events in Myelination by Action Potentials
2011
Overview
Formation of myelin, the electrical insulation on axons produced by oligodendrocytes, is controlled by complex cell-cell signaling that regulates oligodendrocyte development and myelin formation on appropriate axons. If electrical activity could stimulate myelin induction, then neurodevelopment and the speed of information transmission through circuits could be modified by neural activity. We find that release of glutamate from synaptic vesicles along axons of mouse dorsal root ganglion neurons in culture promotes myelin induction by stimulating formation of cholesterol-rich signaling domains between oligodendrocytes and axons, and increasing local synthesis of the major protein in the myelin sheath, myelin basic protein, through Fyn kinase-dependent signaling. This axon-oligodendrocyte signaling would promote myelination of electrically active axons to regulate neural development and function according to environmental experience.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Adenosine Triphosphate - metabolism
/ Animals
/ Axons
/ Biological and medical sciences
/ Fundamental and applied biological sciences. Psychology
/ Ganglia, Spinal - embryology
/ Mice
/ Myelin
/ Myelin Basic Protein - biosynthesis
/ Myelin Basic Protein - genetics
/ Myelin Basic Protein - metabolism
/ Neural Stem Cells - cytology
/ Neural Stem Cells - metabolism
/ Neurons
/ Oligodendroglia - metabolism
/ Proto-Oncogene Proteins c-fyn - metabolism
/ Receptors, Transferrin - metabolism
