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Elr-type proteins protect Xenopus Dead end mRNA from miR-18-mediated clearance in the soma
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Elr-type proteins protect Xenopus Dead end mRNA from miR-18-mediated clearance in the soma
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Elr-type proteins protect Xenopus Dead end mRNA from miR-18-mediated clearance in the soma
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Journal Article
Elr-type proteins protect Xenopus Dead end mRNA from miR-18-mediated clearance in the soma
2010
Overview
Segregation of the future germ line defines a crucial cell fate decision during animal development. In Xenopus, germ cells are specified by inheritance of vegetally localized maternal determinants, including a group of specific mRNAs. Here, we show that the vegetal localization elements (LE) of Xenopus Dead end (XDE) and of several other germ-line-specific, vegetally localized transcripts mediate germ cellspecific stabilization and somatic clearance of microinjected reporter mRNA in Xenopus embryos. The part of XDE-LE critical for somatic RNA clearance exhibits homology to zebrafish nanos1 and appears to be targeted by Xenopus miR-18 for somatic mRNA clearance. Xenopus Elr-type proteins of the vegetal localization complex can alleviate somatic RNA clearance of microinjected XDE-LE and endogenous XDE mRNA. ElrB1 synergizes with Xenopus Dead end protein in the stabilization of XDE-LE mRNA. Taken together, our findings unveil a functional link of vegetal mRNA localization and the protection of germ-line mRNAs from somatic clearance.
Publisher
National Academy of Sciences,National Acad Sciences
Subject
/ Animals
/ Bacteria
/ Cells
/ Embryo, Nonmammalian - metabolism
/ Embryos
/ Female
/ Frogs
/ Gene Expression Regulation, Developmental
/ MicroRNA
/ Oocytes
/ proteins
/ Ribonucleoproteins - genetics
/ Ribonucleoproteins - metabolism
/ RNA
/ RNA-Binding Proteins - genetics
/ RNA-Binding Proteins - metabolism
/ Three prime untranslated regions
/ Xenopus
