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Interleukin 8 and Acute Lung Injury
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Journal Article
Interleukin 8 and Acute Lung Injury
2014
Overview
Acute lung injury is a complex clinical syndrome involving acute inflammation, microvascular damage, and increased pulmonary vascular and epithelial permeability, frequently resulting in acute respiratory failure culminating in often-fatal acute respiratory distress syndrome. Interleukin 8 (IL-8), a potent neutrophil attractant and activator, plays a significant role in acute lung injury via the formation of anti–IL-8 autoantibody:IL-8 complexes and those complexes' interaction with FcγRIIa receptors, leading to the development of acute lung injury by, among other possible mechanisms, effecting neutrophil apoptosis. These complexes may also interact with lung endothelial cells in patients with acute respiratory distress syndrome. Continuing research of the role of neutrophils, IL-8, anti–IL-8 autoantibody:IL-8 complexes, and FcγRIIa receptors may ultimately provide molecular therapies that could lower acute respiratory distress syndrome mortality, as well as reduce or even prevent the development of acute lung injury altogether.
Publisher
College of American Pathologists
Subject
/ Acute Lung Injury - immunology
/ Acute Lung Injury - metabolism
/ Acute Lung Injury - pathology
/ Acute respiratory distress syndrome
/ Animals
/ Biopsy
/ Edema
/ Endothelium, Vascular - immunology
/ Endothelium, Vascular - metabolism
/ Endothelium, Vascular - pathology
/ Humans
/ Kinases
/ Lavage
/ Patients
