Asset Details
Do you wish to reserve the book?
Intermittent versus continuous enteral nutrition attenuates increases in insulin and leptin during short-term bed rest
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Intermittent versus continuous enteral nutrition attenuates increases in insulin and leptin during short-term bed rest
Do you wish to request the book?
Intermittent versus continuous enteral nutrition attenuates increases in insulin and leptin during short-term bed rest
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Intermittent versus continuous enteral nutrition attenuates increases in insulin and leptin during short-term bed rest
2020
Overview
Purpose
To compare endocrine responses to intermittent vs continuous enteral nutrition provision during short-term bed rest.
Methods
Twenty healthy men underwent 7 days of bed rest, during which they were randomized to receive enteral nutrition (47%E as carbohydrate, 34%E as fat, 16%E as protein and 3%E as fibre) in a continuous (CONTINUOUS;
n
= 10; 24 h day
−1
at a constant rate) or intermittent (INTERMITTENT;
n
= 10; as 4 meals per day separated by 5 h) pattern. Daily plasma samples were taken every morning to assess metabolite/hormone concentrations.
Results
During bed rest, plasma leptin concentrations were elevated to a lesser extent with INTERMITTENT vs CONTINUOUS (iAUC: 0.42 ± 0.38 vs 0.95 ± 0.48 nmol L
−1
, respectively;
P
= 0.014) as were insulin concentrations (interaction effect,
P
< 0.001) which reached a peak of 369 ± 225 pmol L
−1
in CONTINUOUS, compared to 94 ± 38 pmol L
−1
in INTERMITTENT (
P
= 0.001). Changes in glucose infusion rate were positively correlated with changes in fasting plasma GLP-1 concentrations (
r
= 0.44,
P
= 0.049).
Conclusion
Intermittent enteral nutrition attenuates the progressive rise in plasma leptin and insulinemia seen with continuous feeding during bed rest, suggesting that continuous feeding increases insulin requirements to maintain euglycemia. This raises the possibility that hepatic insulin sensitivity is impaired to a greater extent with continuous versus intermittent feeding during bed rest. To attenuate endocrine and metabolic changes with enteral feeding, an intermittent feeding strategy may, therefore, be preferable to continuous provision of nutrition.
This trial was registered on clinicaltrials.gov as NCT02521025.
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
