Journal Article

Individualized parcellation of the subthalamic nucleus in patients with Parkinson's disease with 7T MRI

Temel, Yasin, Plantinga, Birgit R., Roebroeck, Alard, Duchin, Yuval, Harel, Noam, ter Haar Romenij, Bart, Vitek, Jerrold, Jahanshahi, Ali, Patriat, Rémi, Kuijf, Mark, Uludağ, Kâmil

2018

Overview

Deep brain stimulation of the subthalamic nucleus (STN) is a widely performed surgical treatment for patients with Parkinson's disease. The goal of the surgery is to place an electrode centered in the motor region of the STN while lowering the effects of electrical stimulation on the non-motor regions. However, distinguishing the motor region from the neighboring associative and limbic areas in individual patients using imaging modalities was until recently difficult to obtain in vivo. Here, using ultra-high field MR imaging, we have performed a dissection of the subdivisions of the STN of individual Parkinson's disease patients. We have acquired 7T diffusion-weighted images of seventeen patients with Parkinson's disease scheduled for deep brain stimulation surgery. Using a structural connectivity-based parcellation protocol, the STN's connections to the motor, limbic, and associative cortical areas were used to map the individual subdivisions of the nucleus. A reproducible patient-specific parcellation of the STN into a posterolateral motor and gradually overlapping central associative area was found in all STNs, taking up on average 55.3% and 55.6% of the total nucleus volume. The limbic area was found in the anteromedial part of the nucleus. Our results suggest that 7T MR imaging may facilitate individualized and highly specific planning of deep brain stimulation surgery of the STN. •The subthalamic nucleus of individual Parkinson patients was parcellated at 7T MRI.•A motor zone was found posterolaterally.•Associative and limbic zones were found more anteriorly and anteromedially.•A gradual overlap of the functional zones was found within the STN.

• Publisher: Elsevier Inc,Elsevier Limited
• Subject: Aged / Deep Brain Stimulation / Diffusion Magnetic Resonance Imaging - methods / Diffusion Magnetic Resonance Imaging - standards / Electrical stimuli / Female / Humans / Image Processing, Computer-Assisted - methods / Image Processing, Computer-Assisted - standards / Magnetic resonance imaging / Male / Middle Aged / Movement disorders / Neural networks / Neurodegenerative diseases / Neuroimaging / NMR / Noise / Nuclear magnetic resonance / Parcellation / Parkinson Disease - diagnostic imaging / Parkinson's disease / Patient-specific / Patients / Reproducibility of Results / Solitary tract nucleus / Subthalamic nucleus / Subthalamic Nucleus - anatomy & histology / Subthalamic Nucleus - diagnostic imaging / Surgery / Ultra-high field MRI