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Structural basis of cycloaddition in biosynthesis of iboga and aspidosperma alkaloids
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Structural basis of cycloaddition in biosynthesis of iboga and aspidosperma alkaloids
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Journal Article
Structural basis of cycloaddition in biosynthesis of iboga and aspidosperma alkaloids
2020
Overview
Cycloaddition reactions generate chemical complexity in a single step. Here we report the crystal structures of three homologous plant-derived cyclases involved in the biosynthesis of iboga and aspidosperma alkaloids. These enzymes act on the same substrate, named angryline, to generate three distinct scaffolds. Mutational analysis reveals how these highly similar enzymes control regio- and stereo-selectivity.
Structural and mutational analysis of three homologous cyclases involved in the biosynthesis of iboga and aspidosperma alkaloids reveals how they convert a common substrate into three distinct scaffolds by controlling regio- and stereoselectivity.
Publisher
Nature Publishing Group US,Nature Publishing Group
