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New sequence variants associated with bone mineral density

by Halldorsson, Bjarni V , Ingvarsson, Thorvaldur , Alexandersen, Peter , Gulcher, Jeffrey R , Stefansson, Kari , Jonsdottir, Thorbjorg , Thorsteinsdottir, Unnur , Saemundsdottir, Jona , Styrkarsdottir, Unnur , Walters, G Bragi , Eisman, John A , Nguyen, Tuan V , Gretarsdottir, Solveig , Gudbjartsson, Daniel F , Christiansen, Claus , Snorradóttir, Steinunn , Center, Jacqueline R , Sigurdsson, Gunnar , Kong, Augustine

in Agriculture / Animal Genetics and Genomics / Base Sequence / Binding sites / Biological and medical sciences / Biomedical and Life Sciences / Biomedicine / Bone density / Bone Density - genetics / Bone mineral density / Bones / brief-communication / Cancer Research / Chromosomes, Human, Pair 17 - genetics / Density / Female / Fractures / Fractures, Bone - complications / Fractures, Bone - genetics / Fundamental and applied biological sciences. Psychology / Gene Function / Genes / Genetic aspects / Genetics of eukaryotes. Biological and molecular evolution / Genome-Wide Association Study / Health aspects / Human Genetics / Humans / Kinases / Male / Physiological aspects / Polymorphism, Single Nucleotide - genetics / Proteins / Risk factors / Sample size / Single nucleotide polymorphisms / Wounds and Injuries - complications / Wounds and Injuries - genetics

2009

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New sequence variants associated with bone mineral density

2009

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2009

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Journal Article

New sequence variants associated with bone mineral density

Halldorsson, Bjarni V,

Ingvarsson, Thorvaldur,

Alexandersen, Peter,

Gulcher, Jeffrey R,

Stefansson, Kari,

Jonsdottir, Thorbjorg,

Thorsteinsdottir, Unnur,

Saemundsdottir, Jona,

Styrkarsdottir, Unnur,

Walters, G Bragi,

Eisman, John A,

Nguyen, Tuan V,

Gretarsdottir, Solveig,

Gudbjartsson, Daniel F,

Christiansen, Claus,

Snorradóttir, Steinunn,

Center, Jacqueline R,

Sigurdsson, Gunnar,

Kong, Augustine

2009

Overview

Unnur Styrkarsdottir and Kari Stefansson and colleagues report the results of an expanded genome-wide association study for bone mineral density at the hip or the spine. New SNP associations were identified downstream of the SOST gene on 17q21, and in intron 1 of the MARK3 gene on 14q32. In an extended genome-wide association study of bone mineral density among 6,865 Icelanders and a follow-up in 8,510 subjects of European descent, we identified four new genome-wide significant loci. These are near the SOST gene at 17q21, the MARK3 gene at 14q32, the SP7 gene at 12q13 and the TNFRSF11A ( RANK ) gene at 18q21. Furthermore, nonsynonymous SNPs in the C17orf53, LRP4, ADAM19 and IBSP genes were suggestively associated with bone density.

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Publisher

Nature Publishing Group US,Nature Publishing Group

Subject

Agriculture

/ Animal Genetics and Genomics

/ Base Sequence

/ Binding sites

/ Biological and medical sciences

/ Biomedical and Life Sciences

/ Biomedicine