Asset Details
Do you wish to reserve the book?
Antibiotic Elution from Hip and Knee Acrylic Bone Cement Spacers: A Systematic Review
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Antibiotic Elution from Hip and Knee Acrylic Bone Cement Spacers: A Systematic Review
Do you wish to request the book?
Antibiotic Elution from Hip and Knee Acrylic Bone Cement Spacers: A Systematic Review
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Antibiotic Elution from Hip and Knee Acrylic Bone Cement Spacers: A Systematic Review
2017
Overview
Knowledge about the elution from antibiotic-loaded cement spacers is an indispensable premise for guarantee of clinical success. A systematic literature search was performed through PubMed. Search terms were “antibiotic elution” and “antibiotic release” in combination with “spacer,” “hip spacer,” and “knee spacer,” respectively. A total of 11 studies could be identified. Seven studies reported on the release of antibiotics after spacer implantation, three studies at spacer removal, and one study on both time points. Seven studies reported on hip spacers, one study on knee spacers, and three studies on both. In eight studies, custom-made spacers have been implanted and in three prefabricated ones. In the majority of the studies, the cement has been loaded with an antibiotic combination, mostly consisting of aminoglycoside (either gentamicin or tobramycin) and vancomycin. Measured concentrations exceeded the minimal inhibitory concentration of the particular pathogen organisms in each case. However, large discrepancies were observed with regard to the height of the antibiotic concentration depending on the antibiotic combination and the antibiotic ratio used. Current literature data indicate a sufficient elution of antibiotics after spacer implantation and at spacer removal, respectively. Future studies are required to optimize the local antibiotic therapy at the site of spacer implantation.
Publisher
Hindawi Publishing Corporation,Hindawi,John Wiley & Sons, Inc
Subject
/ Anti-Bacterial Agents - chemistry
/ Anti-Bacterial Agents - therapeutic use
/ Arthroplasty, Replacement, Hip - methods
/ Bone Cements - therapeutic use
/ Drugs
/ Gentamicins - therapeutic use
/ Humans
/ Knee
/ Knee Prosthesis - microbiology
/ Polymethyl Methacrylate - chemistry
/ Polymethyl Methacrylate - therapeutic use
/ Prosthesis-Related Infections - epidemiology
/ Prosthesis-Related Infections - physiopathology
/ Prosthesis-Related Infections - prevention & control
/ Review
/ Surgery
/ Tobramycin - therapeutic use
/ Vancomycin - therapeutic use
/ Vehicles
