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Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

by Flannick, Jason , Neuberg, Donna , Koistinen, Heikki A , Burtt, Noel , Boehnke, Michael , Kuo, Frank C , Mermel, Craig H , Banahan, Benjamin F , Ladenvall, Claes , Stringham, Heather M , Henderson, Brian , Moltchanov, Vladislav , McCarthy, Mark I , Correa, Adolfo , Higgins, John M , Haiman, Christopher , Manning, Alisa , Lindsley, R. Coleman , Grauman, Peter V , Kinnunen, Leena , Groop, Leif , Gabriel, Stacey , Atzmon, Gil , Chavez, Alejandro , Jaiswal, Siddhartha , Mar, Brenton G , Ebert, Benjamin L , Kluk, Michael J , Kathiresan, Sekar , Tuomilehto, Jaakko , Fontanillas, Pierre , Getz, Gad , Wilson, James G , Altshuler, David

in Adult / Age / Age Factors / Aged / Aged, 80 and over / Biological and medical sciences / Blood / Blood cells / Blood diseases / Cancer / Cardiovascular diseases / Cell differentiation, maturation, development, hematopoiesis / Cell physiology / Cell Transformation, Neoplastic - genetics / Clinical Medicine / Clone Cells / Coronary artery disease / Data processing / Deoxyribonucleic acid / DNA / DNA Mutational Analysis / DNA sequencing / Endocrinology and Diabetes / Endokrinologi och diabetes / Exome / Fundamental and applied biological sciences. Psychology / General aspects / Heart diseases / Hematologic Neoplasms - genetics / Hematological diseases / Hematopoiesis / Hematopoietic Stem Cells - physiology / Humans / Ischemia / Klinisk medicin / Medical and Health Sciences / Medical sciences / Medicin och hälsovetenskap / Middle Aged / Molecular and cellular biology / Mortality / Mutation / Peripheral blood / Phenotypes / Risk Factors / Young Adult

2014

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Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

2014

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2014

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Journal Article

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

Flannick, Jason,

Neuberg, Donna,

Koistinen, Heikki A,

Burtt, Noel,

Boehnke, Michael,

Kuo, Frank C,

Mermel, Craig H,

Banahan, Benjamin F,

Ladenvall, Claes,

Stringham, Heather M,

Henderson, Brian,

Moltchanov, Vladislav,

McCarthy, Mark I,

Correa, Adolfo,

Higgins, John M,

Haiman, Christopher,

Manning, Alisa,

Lindsley, R. Coleman,

Grauman, Peter V,

Kinnunen, Leena,

Groop, Leif,

Gabriel, Stacey,

Atzmon, Gil,

Chavez, Alejandro,

Jaiswal, Siddhartha,

Mar, Brenton G,

Ebert, Benjamin L,

Kluk, Michael J,

Kathiresan, Sekar,

Tuomilehto, Jaakko,

Fontanillas, Pierre,

Getz, Gad,

Wilson, James G,

Altshuler, David

2014

Overview

About 10% of people older than 70 years of age carry one or more mutations in their hematopoietic cells, and these persons have a higher relative risk of a hematologic cancer (by a factor of 11) and of death from cardiovascular disease (by a factor of 2.0 to 2.6). Cancer is thought to arise through the stepwise acquisition of genetic or epigenetic changes that transform a normal cell. 1 Hence, the existence of a premalignant state bearing only the initiating lesions may be detectable in some persons who have no other signs of disease. For example, multiple myeloma is frequently preceded by monoclonal gammopathy of unknown significance, 2 and chronic lymphocytic leukemia is commonly preceded by monoclonal B-cell lymphocytosis. 3 Several lines of evidence have suggested that clonal hematopoiesis resulting from an expansion of cells that harbor an initiating driver mutation might be an aspect of the aging hematopoietic system. Clonal hematopoiesis . . .

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Publisher

Massachusetts Medical Society

Subject

Adult

/ Age

/ Age Factors

/ Aged

/ Aged, 80 and over

/ Biological and medical sciences

/ Blood