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Transcriptional Network Underlying Caenorhabditis elegans Vulval Development
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Transcriptional Network Underlying Caenorhabditis elegans Vulval Development
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Journal Article
Transcriptional Network Underlying Caenorhabditis elegans Vulval Development
2005
Overview
The vulval development of Caenorhabditis elegans provides an opportunity to investigate genetic networks that control gene expression during organogenesis. During the fourth larval stage (L4), seven vulval cell types are produced, each of which executes a distinct gene expression program. We analyze how the expression of cell-type-specific genes is regulated. Ras and Wnt signaling pathways play major roles in generating the spatial pattern of cell types and regulate gene expression through a network of transcription factors. One transcription factor (lin-29) primarily controls the temporal expression pattern. Other transcription factors (lin-11, cog-1, and egl-38) act in combination to control cell-type-specific gene expression. The complexity of the network arises in part because of the dynamic nature of gene expression, in part because of the presence of seven cell types, and also because there are multiple regulatory paths for gene expression within each cell type.
Publisher
National Academy of Sciences,National Acad Sciences
Subject
/ Caenorhabditis elegans - cytology
/ Caenorhabditis elegans - genetics
/ Caenorhabditis elegans - growth & development
/ Caenorhabditis elegans - metabolism
/ Caenorhabditis elegans Proteins - genetics
/ Caenorhabditis elegans Proteins - metabolism
/ Cells
/ DNA-Binding Proteins - genetics
/ DNA-Binding Proteins - metabolism
/ Female
/ Gene Expression Regulation, Developmental
/ Gene Regulatory Networks Special Feature
/ Genes
/ Genetic Complementation Test
/ Intercellular Signaling Peptides and Proteins - genetics
/ Intercellular Signaling Peptides and Proteins - metabolism
/ Transcription Factors - genetics
/ Transcription Factors - metabolism
/ Vulva
