Asset Details
Do you wish to reserve the book?
Human steroidogenesis: implications for controlled ovarian stimulation with exogenous gonadotropins
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Human steroidogenesis: implications for controlled ovarian stimulation with exogenous gonadotropins
Do you wish to request the book?
Human steroidogenesis: implications for controlled ovarian stimulation with exogenous gonadotropins
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Human steroidogenesis: implications for controlled ovarian stimulation with exogenous gonadotropins
2014
Overview
In the menstrual cycle, the mid-cycle surge of gonadotropins (both luteinising hormone [LH] and follicle-stimulating hormone [FSH]) signals the initiation of the periovulatory interval, during which the follicle augments progesterone production and begins to luteinise, ultimately leading to the rupture of the follicle wall and the release of an oocyte. The administration of gonadotropins in controlled ovarian stimulation (COS) leads to supraphysiological steroid concentrations of a very different profile compared with those seen during natural cycles. It has been suggested that these high steroid concentrations cause alterations in endometrial development, affecting oocyte viability in assisted reproductive technology. Furthermore, it has been proposed that elevated progesterone levels have a negative effect on the reproductive outcome of COS. This may arise from an asynchrony between embryo stage and endometrium status at the window of implantation. The regulation of progesterone production by the developing follicles during COS is a complicated interplay of hormonal systems involving the theca and granulosa cells, and the effect of the actions of both LH and FSH. The present paper reviews current knowledge of the regulation of progesterone in the human ovary during the follicular phase and highlights areas where knowledge remains limited. In this review, we provide in-depth information outlining the regulation and function of gonadotropins in the complicated area of steroidogenesis. Based on current evidence, it is not clear whether the high levels of progesterone produced during COS have detrimental effects on fertility.
Publisher
BioMed Central,BioMed Central Ltd
Subject
/ Animals
/ Female
/ Follicle Stimulating Hormone, Human - adverse effects
/ Follicle Stimulating Hormone, Human - genetics
/ Follicle Stimulating Hormone, Human - metabolism
/ Follicle Stimulating Hormone, Human - pharmacology
/ Growth
/ Hormones
/ Humans
/ Infertility, Female - metabolism
/ Infertility, Female - therapy
/ Kinases
/ Luteinizing Hormone - adverse effects
/ Luteinizing Hormone - genetics
/ Luteinizing Hormone - metabolism
/ Luteinizing Hormone - pharmacology
/ Medicine
/ Methods
/ Ovulation Induction - adverse effects
/ Ovulation Induction - methods
/ Recombinant Proteins - adverse effects
/ Recombinant Proteins - metabolism
/ Recombinant Proteins - pharmacology
/ Review
