Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Common variants near TERC are associated with mean telomere length

by van der Harst, Pim , Kimura, Masayuki , Valdes, Ana M , Tobin, Martin D , Ouwehand, Willem , Nelson, Chris , Leach, Irene Mateo , Thompson, John R , Codd, Veryan , Zhai, Guangju , Spector, Tim , Kaiser, Michael , Blackburn, Hannah , Samani, Nilesh J , Rafelt, Suzanne , van Gilst, Wiek H , de Boer, Rudolf A , Hall, Alistair S , van Veldhuisen, Dirk J , Navis, Gerjan , Goodall, Alison H , Aviv, Abraham , Braund, Peter S , Beveridge, Alan J , Moore, Jasbir , Burton, Paul R , Soranzo, Nicole , Mangino, Massimo

in 631/136/7 / 631/208/205 / 631/80/103/560 / Age Factors / Aging / Aging - genetics / Agriculture / Animal Genetics and Genomics / Apoptosis / Biological and medical sciences / Biomedical and Life Sciences / Biomedicine / brief-communication / Cancer Research / Chromosomes / Chromosomes, Human, Pair 3 / Cohort Studies / Fundamental and applied biological sciences. Psychology / Gene Frequency / Gene Function / Gene therapy / Genetic aspects / Genetic variation / Genetics / Genetics of eukaryotes. Biological and molecular evolution / Genome-Wide Association Study / Human Genetics / Humans / Meta-Analysis as Topic / Physiological aspects / Polymorphism, Single Nucleotide - physiology / Quantitative Trait Loci / RNA - genetics / RNA - physiology / Structure / Telomerase - genetics / Telomerase - physiology / Telomere - genetics / Telomere - metabolism / Telomeres / Time Factors

2010

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Common variants near TERC are associated with mean telomere length

2010

Confirm

Do you wish to request the book?

Common variants near TERC are associated with mean telomere length

2010

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Common variants near TERC are associated with mean telomere length

van der Harst, Pim,

Kimura, Masayuki,

Valdes, Ana M,

Tobin, Martin D,

Ouwehand, Willem,

Nelson, Chris,

Leach, Irene Mateo,

Thompson, John R,

Codd, Veryan,

Zhai, Guangju,

Spector, Tim,

Kaiser, Michael,

Blackburn, Hannah,

Samani, Nilesh J,

Rafelt, Suzanne,

van Gilst, Wiek H,

de Boer, Rudolf A,

Hall, Alistair S,

van Veldhuisen, Dirk J,

Navis, Gerjan,

Goodall, Alison H,

Aviv, Abraham,

Braund, Peter S,

Beveridge, Alan J,

Moore, Jasbir,

Burton, Paul R,

Soranzo, Nicole,

Mangino, Massimo

2010

Overview

Nilesh Samani and colleagues report a genome-wide association study that identifies variants near the TERC locus associated to variance in mean telomere length. We conducted genome-wide association analyses of mean leukocyte telomere length in 2,917 individuals, with follow-up replication in 9,492 individuals. We identified an association with telomere length on 3q26 (rs12696304, combined P = 3.72 × 10 −14 ) at a locus that includes TERC , which encodes the telomerase RNA component. Each copy of the minor allele of rs12696304 was associated with an ∼75-base-pair reduction in mean telomere length, equivalent to ∼3.6 years of age-related telomere-length attrition.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group US,Nature Publishing Group

Subject

/ Aging