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Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics?
by
Benvenuto, Domenico
, Pascarella, Stefano
, Angeletti, Silvia
, Bianchi, Martina
, Ciccozzi, Massimo
, Giovanetti, Marta
in
Alphacoronavirus - chemistry
/ Alphacoronavirus - classification
/ Alphacoronavirus - genetics
/ Amino Acid Sequence
/ Animals
/ Betacoronavirus - chemistry
/ Betacoronavirus - classification
/ Betacoronavirus - genetics
/ Chiroptera - virology
/ Coronaviridae
/ Coronaviridae - chemistry
/ Coronaviridae - classification
/ Coronaviridae - genetics
/ Coronavirus Envelope Proteins
/ Coronavirus Infections - virology
/ Coronaviruses
/ COVID-19
/ Disease transmission
/ Eutheria - virology
/ Genomes
/ Genomic analysis
/ Glycoproteins
/ Health aspects
/ Homology
/ Humans
/ Membrane proteins
/ Membranes
/ Models, Molecular
/ Mutation
/ Pandemics
/ Pneumonia, Viral - virology
/ Protein Conformation
/ Proteins
/ SARS-CoV-2
/ Sequence Homology, Amino Acid
/ Severe acute respiratory syndrome
/ Severe acute respiratory syndrome coronavirus 2
/ Species Specificity
/ Structural Homology, Protein
/ Viral diseases
/ Viral Envelope Proteins - chemistry
/ Viral Envelope Proteins - genetics
/ Viral Matrix Proteins - chemistry
/ Viral Matrix Proteins - genetics
/ Virus diseases
/ Viruses
2020
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Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics?
by
Benvenuto, Domenico
, Pascarella, Stefano
, Angeletti, Silvia
, Bianchi, Martina
, Ciccozzi, Massimo
, Giovanetti, Marta
in
Alphacoronavirus - chemistry
/ Alphacoronavirus - classification
/ Alphacoronavirus - genetics
/ Amino Acid Sequence
/ Animals
/ Betacoronavirus - chemistry
/ Betacoronavirus - classification
/ Betacoronavirus - genetics
/ Chiroptera - virology
/ Coronaviridae
/ Coronaviridae - chemistry
/ Coronaviridae - classification
/ Coronaviridae - genetics
/ Coronavirus Envelope Proteins
/ Coronavirus Infections - virology
/ Coronaviruses
/ COVID-19
/ Disease transmission
/ Eutheria - virology
/ Genomes
/ Genomic analysis
/ Glycoproteins
/ Health aspects
/ Homology
/ Humans
/ Membrane proteins
/ Membranes
/ Models, Molecular
/ Mutation
/ Pandemics
/ Pneumonia, Viral - virology
/ Protein Conformation
/ Proteins
/ SARS-CoV-2
/ Sequence Homology, Amino Acid
/ Severe acute respiratory syndrome
/ Severe acute respiratory syndrome coronavirus 2
/ Species Specificity
/ Structural Homology, Protein
/ Viral diseases
/ Viral Envelope Proteins - chemistry
/ Viral Envelope Proteins - genetics
/ Viral Matrix Proteins - chemistry
/ Viral Matrix Proteins - genetics
/ Virus diseases
/ Viruses
2020
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Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics?
by
Benvenuto, Domenico
, Pascarella, Stefano
, Angeletti, Silvia
, Bianchi, Martina
, Ciccozzi, Massimo
, Giovanetti, Marta
in
Alphacoronavirus - chemistry
/ Alphacoronavirus - classification
/ Alphacoronavirus - genetics
/ Amino Acid Sequence
/ Animals
/ Betacoronavirus - chemistry
/ Betacoronavirus - classification
/ Betacoronavirus - genetics
/ Chiroptera - virology
/ Coronaviridae
/ Coronaviridae - chemistry
/ Coronaviridae - classification
/ Coronaviridae - genetics
/ Coronavirus Envelope Proteins
/ Coronavirus Infections - virology
/ Coronaviruses
/ COVID-19
/ Disease transmission
/ Eutheria - virology
/ Genomes
/ Genomic analysis
/ Glycoproteins
/ Health aspects
/ Homology
/ Humans
/ Membrane proteins
/ Membranes
/ Models, Molecular
/ Mutation
/ Pandemics
/ Pneumonia, Viral - virology
/ Protein Conformation
/ Proteins
/ SARS-CoV-2
/ Sequence Homology, Amino Acid
/ Severe acute respiratory syndrome
/ Severe acute respiratory syndrome coronavirus 2
/ Species Specificity
/ Structural Homology, Protein
/ Viral diseases
/ Viral Envelope Proteins - chemistry
/ Viral Envelope Proteins - genetics
/ Viral Matrix Proteins - chemistry
/ Viral Matrix Proteins - genetics
/ Virus diseases
/ Viruses
2020
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Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics?
Journal Article
Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics?
2020
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Overview
The Coronavirus Disease 2019 (COVID-19) is a new viral infection caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2). Genomic analyses have revealed that SARS-CoV-2 is related to Pangolin and Bat coronaviruses. In this report, a structural comparison between the Sars-CoV-2 Envelope and Membrane proteins from different human isolates with homologous proteins from closely related viruses is described. The analyses here reported show the high structural similarity of Envelope and Membrane proteins to the counterparts from Pangolin and Bat coronavirus isolates. However, the comparisons have also highlighted structural differences specific of Sars-CoV-2 proteins which may be correlated to the cross-species transmission and/or to the properties of the virus. Structural modelling has been applied to map the variant sites onto the predicted three-dimensional structure of the Envelope and Membrane proteins.
Publisher
Hindawi Publishing Corporation,Hindawi,John Wiley & Sons, Inc
Subject
/ Alphacoronavirus - classification
/ Animals
/ Betacoronavirus - classification
/ Coronaviridae - classification
/ Coronavirus Envelope Proteins
/ Coronavirus Infections - virology
/ COVID-19
/ Genomes
/ Homology
/ Humans
/ Mutation
/ Proteins
/ Sequence Homology, Amino Acid
/ Severe acute respiratory syndrome
/ Severe acute respiratory syndrome coronavirus 2
/ Structural Homology, Protein
/ Viral Envelope Proteins - chemistry
/ Viral Envelope Proteins - genetics
/ Viral Matrix Proteins - chemistry
/ Viral Matrix Proteins - genetics
/ Viruses
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