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Administration of Apple Polyphenol Supplements for Skin Conditions in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
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Administration of Apple Polyphenol Supplements for Skin Conditions in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
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Administration of Apple Polyphenol Supplements for Skin Conditions in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
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Journal Article
Administration of Apple Polyphenol Supplements for Skin Conditions in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
2020
Overview
This clinical study was performed to evaluate the effects of continuous apple polyphenol (AP) administration on facial skin conditions and pigmentation induced by ultraviolet (UV) irradiation in healthy women participants. Participants (n = 65, age 20–39 years) were randomized to receive tablets containing AP (300 or 600 mg/day) or placebo in a double-blinded, placebo-controlled clinical trial. Continuous administration of AP for 12 weeks significantly prevented UV irradiation induced skin pigmentation (erythema value, melanin value, L value), although a dose-dependent relationship was not clearly observed. In contrast, no significant differences were detected between the groups with regard to water content and trans-epidermal water loss. Our study demonstrated that APs and their major active compounds, procyanidins, have several health benefits. Here, we report that continuous administration of AP for 12 weeks alleviated UV irradiation induced skin pigmentation, when compared with placebo, in healthy women.
Publisher
MDPI AG,MDPI
Subject
/ Adult
/ age
/ Apples
/ Chlorogenic Acid - administration & dosage
/ Chlorogenic Acid - pharmacology
/ Dose-Response Relationship, Drug
/ Enzymes
/ Erythema
/ Female
/ Flavonoids - administration & dosage
/ Humans
/ Male
/ melanin
/ placebos
/ Proanthocyanidins - administration & dosage
/ Proanthocyanidins - pharmacology
/ Skin
/ Skin Diseases - prevention & control
/ Skin Pigmentation - drug effects
/ Skin Pigmentation - radiation effects
/ Tannins
/ Tannins - administration & dosage
/ Tea
/ Ultraviolet Rays - adverse effects
/ water
/ Water Loss, Insensible - drug effects
/ Water Loss, Insensible - radiation effects
/ women
