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A Pooled Analysis of Bone Marrow Micrometastasis in Breast Cancer
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A Pooled Analysis of Bone Marrow Micrometastasis in Breast Cancer
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Journal Article
A Pooled Analysis of Bone Marrow Micrometastasis in Breast Cancer
2005
Overview
In a pooled analysis of nine clinical trials involving almost 5000 women with breast cancer who underwent examination of the bone marrow for metastatic cancer cells, the presence of metastases in the bone marrow at the time of diagnosis of breast cancer was associated with a poor prognosis.
In trials involving almost 5000 women with breast cancer, the presence of micrometastases in the bone marrow at the time of diagnosis of breast cancer was associated with a poor prognosis.
Data from experiments in animals
1
performed in the 1960s and from more recent immunocytochemical
2
,
3
and molecular
4
,
5
studies suggest that lymph-node involvement does not accurately predict hematogenous dissemination of cancer cells, nor is hematogenous dissemination necessarily associated with lymph-node involvement.
6
,
7
During the past two decades, several studies have assessed the prevalence and prognostic value of hematogenous dissemination of tumor cells in patients with node-positive and node-negative breast cancer.
3
,
8
–
15
The influence of the presence of micrometastasis in the bone marrow on prognosis has been shown in patients with identical stages of breast cancer, as defined by tumor . . .
Publisher
Massachusetts Medical Society
