Journal Article

Antibodies to measles, mumps, and rubella virus in Thai children after two-dose vaccination at 9 months and 2.5 years: A longitudinal study

Wanlapakorn, Nasamon, Srimuan, Donchida, Poovorawan, Yong, Thatsanathorn, Thaksaporn, Vongpunsawad, Sompong, Thongmee, Thanunrat, Puenpa, Jiratchaya

2020

Overview

Thailand changed the schedule of childhood measles–mumps–rubella (MMR) vaccination in 2014, moving the second dose from the age of 6 years to 2.5 years. There are currently no data on antibody responses to the MMR vaccine since this recommendation. We investigated antibody responses in a cohort of children who received two doses of MMR vaccine at the ages of 9 months and 2.5 years that was originally established to evaluate antibody levels to Bordetella pertussis antigens (ClinicalTrials.gov no. NCT02408926). Infants were born to mothers who previously received tetanus–diphtheria–acellular pertussis vaccine at 27–36 weeks of gestation. Anti-measles, -mumps, and -rubella virus IgG levels were measured at birth (cord blood) and the ages of 2 and 7 months (before the first MMR vaccination); 18 and 24 months (9 and 15 months, respectively, after the first dose); and 36 months (6 months after the second dose) using commercially available enzyme-linked immunosorbent assay kits. At 7 months of age, 96.2%, 99.6%, and 98.8% of infants had no protection against measles, mumps, and rubella, respectively. Levels of antibody against all three antigens increased significantly after the first but not the second dose. At 6 months after two-dose vaccination, 97.4%, 84.8%, and 78.7% of children remained seroprotected against measles, mumps, and rubella, respectively. Maternally derived antibodies to measles, mumps, and rubella virus disappeared by the age of 7 months in Thai children. Two-dose MMR vaccination at 9 months and 2.5 years of age induced robust immune responses against these viruses.

• Publisher: Elsevier Ltd,Elsevier Limited
• Subject: Age / Allergy and Immunology / Antibodies / Antibodies, Viral - blood / antibody formation / Antigens / Biological products / blood / Bordetella pertussis / Chicken pox / Child / childhood / Childhood vaccination / Children / Cord blood / Correlation analysis / Diphtheria / Enzyme-linked immunosorbent assay / Epidemics / Genotype & phenotype / Gestation / Hepatitis / Humans / Immune response / Immunization Schedule / Immunoglobulin G / Infant / Infants / Longitudinal Studies / Measles / Measles - prevention & control / Measles-Mumps-Rubella Vaccine - administration & dosage / Measles-Mumps-Rubella Vaccine - immunology / Measles–mumps–rubella (MMR) / mothers / Mumps / Mumps - prevention & control / Pertussis / Poliomyelitis / pregnancy / Public health / Rabies / Recommender systems / Rubella / Rubella - prevention & control / Rubella virus / Schedules / Seroprotection / Tetanus / Thai people / Thailand / Two-dose vaccine / Vaccination / Vaccines / Viruses / Whooping cough / Womens health