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A ‘parameiosis’ drives depolyploidization and homologous recombination in Candida albicans
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A ‘parameiosis’ drives depolyploidization and homologous recombination in Candida albicans
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Journal Article
A ‘parameiosis’ drives depolyploidization and homologous recombination in Candida albicans
2019
Overview
Meiosis is a conserved tenet of sexual reproduction in eukaryotes, yet this program is seemingly absent from many extant species. In the human fungal pathogen
Candida albicans
, mating of diploid cells generates tetraploid products that return to the diploid state via a non-meiotic process of depolyploidization known as concerted chromosome loss (CCL). Here, we report that recombination rates are more than three orders of magnitude higher during CCL than during normal mitotic growth. Furthermore, two conserved ‘meiosis-specific’ factors play central roles in CCL as
SPO11
mediates DNA double-strand break formation while both
SPO11
and
REC8
regulate chromosome stability and promote inter-homolog recombination. Unexpectedly,
SPO11
also promotes DNA repair and recombination during normal mitotic divisions. These results indicate that
C. albicans
CCL represents a ‘parameiosis’ that blurs the conventional boundaries between mitosis and meiosis. They also reveal parallels with depolyploidization in mammalian cells and provide potential insights into the evolution of meiosis.
Mating of
Candida albicans
produces tetraploid products that return to the diploid state via a non-meiotic process known as concerted chromosome loss (CCL). Here, Anderson et al. show high recombination rates during CCL and identify factors that are essential for chromosome stability and recombination during CCL.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 45/29
/ 45/41
/ 45/70
/ 49/1
/ 49/31
/ Chromosomes, Fungal - genetics
/ Diploidy
/ DNA
/ Endodeoxyribonucleases - genetics
/ Endodeoxyribonucleases - metabolism
/ Fungal Proteins - metabolism
/ Homologous Recombination - genetics
/ Homology
/ Humanities and Social Sciences
/ Humans
/ Meiosis
/ Mitosis
/ Rec A Recombinases - genetics
/ Rec A Recombinases - metabolism
/ Science
/ Science & Technology - Other Topics
/ Yeast
