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Lipopolysaccharide O-antigen delays plant innate immune recognition of Xylella fastidiosa
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Lipopolysaccharide O-antigen delays plant innate immune recognition of Xylella fastidiosa
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Journal Article
Lipopolysaccharide O-antigen delays plant innate immune recognition of Xylella fastidiosa
2018
Overview
Lipopolysaccharides (LPS) are among the known pathogen-associated molecular patterns (PAMPs). LPSs are potent elicitors of PAMP-triggered immunity (PTI), and bacteria have evolved intricate mechanisms to dampen PTI. Here we demonstrate that
Xylella fastidiosa
(
Xf
), a hemibiotrophic plant pathogenic bacterium, possesses a long chain O-antigen that enables it to delay initial plant recognition, thereby allowing it to effectively skirt initial elicitation of innate immunity and establish itself in the host. Lack of the O-antigen modifies plant perception of
Xf
and enables elicitation of hallmarks of PTI, such as ROS production specifically in the plant xylem tissue compartment, a tissue not traditionally considered a spatial location of PTI. To explore translational applications of our findings, we demonstrate that pre-treatment of plants with
Xf
LPS primes grapevine defenses to confer tolerance to
Xf
challenge.
Many pathogenic bacteria have evolved to subvert host immune responses triggered by lipopolysaccharides (LPS). Here the authors show that a long terminal polysaccharide chain, known as the O-antigen, present in LPS from the plant pathogen
Xylella fastidiosa
can delay recognition by grapevine hosts.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Antigens
/ Bacteria
/ Gene Expression Regulation, Plant - immunology
/ Host-Pathogen Interactions - immunology
/ Humanities and Social Sciences
/ Immunity
/ Immunity, Innate - immunology
/ Lipopolysaccharides - immunology
/ Lipopolysaccharides - metabolism
/ Plant Diseases - microbiology
/ Science
/ Xylem
